Intensive Care Medicine

, Volume 34, Issue 1, pp 132–137

An underrecognized source of organ donors: patients with brain death after successfully resuscitated cardiac arrest

  • Christophe Adrie
  • Hakim Haouache
  • Mohamed Saleh
  • Nathalie Memain
  • Ivan Laurent
  • Marie Thuong
  • Loic Darques
  • Patrice Guerrini
  • Mehran Monchi
Original

DOI: 10.1007/s00134-007-0885-7

Cite this article as:
Adrie, C., Haouache, H., Saleh, M. et al. Intensive Care Med (2008) 34: 132. doi:10.1007/s00134-007-0885-7

Abstract

Objective

To identify predictors of brain death after successful resuscitation of out-of-hospital cardiac arrest (OHCA), with the goal of improving the detection of brain death, and to evaluate outcomes of solid organs harvested from these patients.

Design and setting

Prospective observational cohort study in a medical and surgical unit of a nonuniversity hospital.

Patients

Patients with successfully resuscitated OHCA were prospectively included in a database over a 7-year period. We looked for early predictors of brain death and compared outcomes of organ transplants from these patients to those from patients with brain death due to head injury or stroke.

Results

Over the 7-year period 246 patients were included. No early predictors of brain death were found. Of the 40 patients (16%) who met criteria for brain death, after a median ICU stay of 2.5 days (IQR 2.0–4.2), 19 donated 52 solid organs (29 kidneys, 14 livers, 7 hearts, and 2 lungs). Outcomes of kidneys and livers did not differ between donors with and without resuscitated cardiac arrest.

Conclusions

Brain death may occur in about one-sixth of patients after successfully resuscitated OHCA, creating opportunities for organ donation.

Keywords

Cardiac arrestBrain deathOrgan donationOutcome

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Christophe Adrie
    • 1
  • Hakim Haouache
    • 1
  • Mohamed Saleh
    • 1
  • Nathalie Memain
    • 1
  • Ivan Laurent
    • 2
  • Marie Thuong
    • 1
  • Loic Darques
    • 1
  • Patrice Guerrini
    • 3
  • Mehran Monchi
    • 2
  1. 1.Intensive Care UnitDelafontaine HospitalSaint DenisFrance
  2. 2.Intensive Care UnitJacques Cartier HospitalMassyFrance
  3. 3.Agence de BiomédicineKremlin Bicêtre HospitalLe Kremlin BicêtreFrance