Intensive Care Medicine

, Volume 33, Issue 7, pp 1199–1203

Insertion/deletion polymorphism in the promoter of NFKB1 influences severity but not mortality of acute respiratory distress syndrome

Authors

    • Institut für Pharmakogenetik, University Hospital EssenUniversity of Duisburg-Essen
    • Klinik für Anästhesiologie und Intensivmedizin, University Hospital EssenUniversity of Duisburg-Essen
  • Ulrich H. Frey
    • Institut für Pharmakogenetik, University Hospital EssenUniversity of Duisburg-Essen
    • Klinik für Anästhesiologie und Intensivmedizin, University Hospital EssenUniversity of Duisburg-Essen
  • Kathrin Rieman
    • Institut für Pharmakogenetik, University Hospital EssenUniversity of Duisburg-Essen
  • Stephan Sixt
    • Klinik für Anästhesiologie und Intensivmedizin, University Hospital EssenUniversity of Duisburg-Essen
  • Martin Beiderlinden
    • Klinik für Anästhesiologie und Intensivmedizin, University Hospital EssenUniversity of Duisburg-Essen
  • Winfried Siffert
    • Institut für Pharmakogenetik, University Hospital EssenUniversity of Duisburg-Essen
  • Jürgen Peters
    • Klinik für Anästhesiologie und Intensivmedizin, University Hospital EssenUniversity of Duisburg-Essen
Brief Report

DOI: 10.1007/s00134-007-0649-4

Cite this article as:
Adamzik, M., Frey, U.H., Rieman, K. et al. Intensive Care Med (2007) 33: 1199. doi:10.1007/s00134-007-0649-4

Abstract

Objective

This study investigated whether the insertion/deletion polymorphism in the promoter of NFKB1 is associated with severity and/or mortality in ARDS.

Design and setting

Prospective study in a mixed anesthesiological ICU of the University Hospital Essen.

Patients and participants

103 adult patients with ARDS (white Germans).

Measurements and results

Patients with ARDS were genotyped for the insertion/deletion polymorphism in the promoter of NFKB1 (−94ins/delATTG). In ARDS patients genotypes differed significantly between those with severe ARDS [Lung Injury Score (LIS) ≥ 3; 23 homozygote deletion (DD), heterozygote (ID) 31, and homozygote insertion wildtype (II) 23], and those with LIS below 3 (1 DD, 9 ID, 16 II). Likewise, the frequency of the D allele was significantly less in patients with higher LIS (50% D) than lower LIS (21% D). Using these values produces a significantly higher OR of 16.0 (95% CI 1.96–130.9) for DD than for II, while the OR for ID vs. II was 2.4 (95% CI 0.9–6.4). Genotypes of the NFKB1 promoter polymorphism were associated neither with 30-day survival nor with duration of ICU stay.

Conclusions

The insertion/deletion polymorphism in the promoter of NFKB1 influences the severity but not the mortality of ARDS.

Keywords

Acute respiratory distress syndromeGenotypingInsertion/deletion polymorphismNFKB1 promoterNuclear factor κB

Copyright information

© Springer-Verlag 2007