Intensive Care Medicine

, Volume 33, Issue 1, pp 148–152

Decrease in circulating dendritic cells predicts fatal outcome in septic shock

  • Olivier Guisset
  • Marie-Sarah Dilhuydy
  • Rodolphe Thiébaut
  • Jérôme Lefèvre
  • Fabrice Camou
  • Anne Sarrat
  • Claude Gabinski
  • Jean-François Moreau
  • Patrick Blanco
Brief Report

DOI: 10.1007/s00134-006-0436-7

Cite this article as:
Guisset, O., Dilhuydy, MS., Thiébaut, R. et al. Intensive Care Med (2007) 33: 148. doi:10.1007/s00134-006-0436-7

Abstract

Objective

Biomarkers allowing accurate early staging of septic shock patients are lacking despite their obvious interest for patient management. Experimental models of septic shock in mouse previously noted a decrease in dendritic cell numbers. The aim of the study was to find a rapid reproducible biological test for an assessment of disease severity.

Design

Evaluation of peripheral blood dendritic cell counts by flow cytometry using three commercially available kits.

Patients and participants

Forty-two consecutive septic shock patients were studied prospectively.

Measurements and results

Early low dendritic cell counts were correlated to disease severity as assessed by Simplified Acute Physiology Score or Sequential Organ Failure Assessment and predicted fatal outcome. The correlation was still present when the results were adjusted for age.

Conclusion

The monitoring of blood dendritic cell count may provide an early and valuable assessment of the severity of the host response against infection and may influence the therapeutic management of septic shock patients.

Keywords

Septic shock Dendritic cell Sepsis Infection 

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Olivier Guisset
    • 1
  • Marie-Sarah Dilhuydy
    • 1
  • Rodolphe Thiébaut
    • 2
  • Jérôme Lefèvre
    • 1
  • Fabrice Camou
    • 1
  • Anne Sarrat
    • 3
  • Claude Gabinski
    • 1
  • Jean-François Moreau
    • 3
  • Patrick Blanco
    • 3
  1. 1.Département de Réanimation Médicale et UrgencesHôpital St André, CHU de BordeauxBordeauxFrance
  2. 2.INSERM E0338 and INSERM U593, ISPEDUniversité Bordeaux 2BordeauxFrance
  3. 3.Laboratoire ImmunologieHôpital Pellegrin, CHU de BordeauxBordeaux CedexFrance

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