Intensive Care Medicine

, Volume 32, Issue 12, pp 1979–1986

Effect of inspired oxygen fraction on alveolar derecruitment in acute respiratory distress syndrome

  • Jérôme Aboab
  • Bjorn Jonson
  • Achille Kouatchet
  • Solenne Taille
  • Lisbet Niklason
  • Laurent Brochard
Original

DOI: 10.1007/s00134-006-0382-4

Cite this article as:
Aboab, J., Jonson, B., Kouatchet, A. et al. Intensive Care Med (2006) 32: 1979. doi:10.1007/s00134-006-0382-4

Abstract

Objective

High fractions of inspired oxygen (FIO2) used in acute lung injury (ALI) may promote resorption atelectasis. The impact of derecruitment related to high FIO2 in ALI is debated. We evaluated derecruitment with 100% vs. 60% FIO2 at two levels of positive end-expiratory pressure (PEEP).

Patients

Fourteen consecutive patients with ALI were studied.

Interventions

Recruited volume at two PEEP levels was computed from two pressure-volume curves, recorded from PEEP and from zero end-expiratory pressure, using the sinusoidal flow modulation method. PEEP-induced recruitment was measured during prolonged expiration as the difference between the two curves at a given pressure. PaO2/FIO2 was also measured. PEEP was 5 ± 1 or 14 ± 3 cmH2O and FIO2 was 60% or 100%, yielding four combinations. We looked for differences between the beginning and end of a 30-min period with each combination.

Measurement and results

With low PEEP and 100% FIO2, recruited volume decreased significantly from 68 ± 53 to 39 ± 43 ml and PaO2/FIO2 from 196 ± 104 to 153 ± 83 mmHg. With the three other combinations (low PEEP and 60% FIO2 or high PEEP and 60% or 100% FIO2) none of the parameters decreased significantly.

Conclusion

In mechanically ventilated patients with ALI the breathing of pure oxygen leads to derecruitment, which is prevented by high PEEP.

Keywords

Acute respiratory distress syndromeAcute lung injuryAtelectasisOxygen inhalationOxygen toxicity

Supplementary material

134_2006_382_MOESM1_ESM.doc (38 kb)
Electronic Supplementary Material (DOC 38K)

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Jérôme Aboab
    • 1
  • Bjorn Jonson
    • 2
  • Achille Kouatchet
    • 1
  • Solenne Taille
    • 1
  • Lisbet Niklason
    • 2
  • Laurent Brochard
    • 1
    • 3
  1. 1.Service de Réanimation Médicale de l’hôpital Henri MondorCréteilFrance
  2. 2.Department of Clinical PhysiologyUniversity HospitalLundSweden
  3. 3.INSERM Unit 651Faculté de Médecine Paris 12CréteilFrance