, Volume 32, Issue 4, pp 624-625
Date: 14 Feb 2006

Nocturnal melatonin concentration is correlated with illness severity in patients with septic disease

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Sir: Disturbances of pineal function are well known in critically ill humans [1], but it is unclear whether melatonin blood concentrations are related to severity of illness. We measured serum melatonin concentrations at 2 a.m. in the first night in hospital in 302 patients consecutively admitted to the medical ICU of the University Hospital in Lübeck, Germany. At the same time the Acute Physiology And Chronic Health Evaluation (APACHE) II score and Therapeutic Intervention Scoring System (TISS) were assessed. Serum melatonin concentrations were determined by enzyme-linked immunosorbent assay (DPC Biermann, Germany). Correlations between illness severity and serum melatonin concentrations were calculated for the whole group and also for subgroups of patients specified according to the main diagnosis before the study. Results were presented at the annual congress of the ESCIM in Amsterdam, 25 September 2005 [2].

Overall analysis for the whole group of patients revealed no correlation bet ...