Intensive Care Medicine

, Volume 31, Issue 11, pp 1514–1521

Invasive candidiasis: comparison of management choices by infectious disease and critical care specialists

  • Philippe Eggimann
  • Thierry Calandra
  • Ursula Fluckiger
  • Jacques Bille
  • Jorge Garbino
  • Michel-Pierre Glauser
  • Oscar Marchetti
  • Christian Ruef
  • Martin Täuber
  • Didier Pittet
  • for the Fungal Infection Network of Switzerland (FUNGINOS)
Original

DOI: 10.1007/s00134-005-2809-8

Cite this article as:
Eggimann, P., Calandra, T., Fluckiger, U. et al. Intensive Care Med (2005) 31: 1514. doi:10.1007/s00134-005-2809-8

Abstract

Objective

To compare the management of invasive candidiasis between infectious disease and critical care specialists.

Design and setting

Clinical case scenarios of invasive candidiasis were presented during interactive sessions at national specialty meetings. Participants responded to questions using an anonymous electronic voting system.

Patients and participants

Sixty-five infectious disease and 51 critical care physicians in Switzerland.

Results

Critical care specialists were more likely to ask advice from a colleague with expertise in the field of fungal infections to treat Candida glabrata (19.5% vs. 3.5%) and C. krusei (36.4% vs. 3.3%) candidemia. Most participants reported that they would change or remove a central venous catheter in the presence of candidemia, but 77.1% of critical care specialists would start concomitant antifungal treatment, compared to only 50% of infectious disease specialists. Similarly, more critical care specialists would start antifungal prophylaxis when Candida spp. are isolated from the peritonal fluid at time of surgery for peritonitis resulting from bowel perforation (22.2% vs. 7.2%). The two groups equally considered Candida spp. as pathogens in tertiary peritonitis, but critical care specialists would more frequently use amphotericin B than fluconazole, caspofungin, or voriconazole. In mechanically ventilated patients the isolation of 104 Candida spp. from a bronchoalveolar lavage was considered a colonizing organism by 94.9% of infectious disease, compared to 46.8% of critical care specialists, with a marked difference in the use of antifungal agents (5.1% vs. 51%).

Conclusions

These data highlight differences between management approaches for candidiasis in two groups of specialists, particularly in the reported use of antifungals.

Keywords

Antifungal treatmentCritical care specialistsInfectious diseaseInvasive candidiasisSwitzerlandTreatment survey

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Philippe Eggimann
    • 1
    • 8
  • Thierry Calandra
    • 2
  • Ursula Fluckiger
    • 3
  • Jacques Bille
    • 4
  • Jorge Garbino
    • 5
  • Michel-Pierre Glauser
    • 2
  • Oscar Marchetti
    • 2
  • Christian Ruef
    • 6
  • Martin Täuber
    • 7
  • Didier Pittet
    • 1
    • 5
  • for the Fungal Infection Network of Switzerland (FUNGINOS)
  1. 1.Infection Control ProgramUniversity of Geneva HospitalsGeneva 14Switzerland
  2. 2.Infectious Diseases Service, Department of Internal MedicineCentre Hospitalier Universitaire VaudoisLausanneSwitzerland
  3. 3.Division of Infectious DiseasesUniversity HospitalBaselSwitzerland
  4. 4.Institute of MicrobiologyCentre Hospitalier Universitaire VaudoisLausanneSwitzerland
  5. 5.Division of Infectious Diseases, Department of Internal MedicineUniversity of Geneva HospitalsGenevaSwitzerland
  6. 6.Division of Infection Control and PreventionUniversitätsspitalZurichSwitzerland
  7. 7.Institute for Infectious DiseasesUniversity of BernBernSwitzerland
  8. 8.Surgical ICU and Burn UnitCentre Hospitalier Universitaire VaudoisLausanneSwitzerland