Intensive Care Medicine

, Volume 31, Issue 5, pp 638–644

Effects of levosimendan on systemic and regional hemodynamics in septic myocardial depression

  • Andrea Morelli
  • Stefano De Castro
  • Jean-Louis Teboul
  • Mervyn Singer
  • Monica Rocco
  • Giorgio Conti
  • Leonardo De Luca
  • Emanuele Di Angelantonio
  • Alessandra Orecchioni
  • Natesa G. Pandian
  • Paolo Pietropaoli
Original

DOI: 10.1007/s00134-005-2619-z

Cite this article as:
Morelli, A., De Castro, S., Teboul, JL. et al. Intensive Care Med (2005) 31: 638. doi:10.1007/s00134-005-2619-z

Abstract

Objective

Calcium desensitization plays an important part in the pathophysiology of septic myocardial depression. We postulated that levosimendan, a new calcium sensitizer, would be beneficial in sepsis-induced cardiac dysfunction.

Design and setting

Prospective, randomized, controlled study in two university hospital intensive care units

Patients and participants

Twenty-eight patients with persisting left ventricular dysfunction related to septic shock after 48 h of conventional treatment including dobutamine (5 µg/kg per minute).

Interventions

After 48 h of conventional treatment patients were randomized to receive a 24-h infusion of either levosimendan (0.2 µg/kg per minute, n=15) or dobutamine (5 µg/kg per minute, n=13).

Measurements and results

Data from right heart catheterization, echocardiography, gastric tonometry, laser-Doppler flowmetry, and lactate concentrations and creatinine clearance were obtained before and after the 24-h drug infusion. Dobutamine did not change systemic or regional hemodynamic variables. By contrast, at the same mean arterial pressure levosimendan decreased pulmonary artery occlusion pressure and increased cardiac index. Levosimendan decreased left ventricular end-diastolic volume and increased left ventricular ejection fraction. Levosimendan increased gastric mucosal flow, creatinine clearance, and urinary output while it decreased lactate concentrations.

Conclusions

These findings show that levosimendan improves systemic hemodynamics and regional perfusion in patients with septic cardiac dysfunction under conditions where administration of 5 µg/kg dobutamine per minute is no longer efficacious. Accordingly, our results suggest that levosimendan can be an alternative to the strategy of increasing the dose of dobutamine under such conditions.

Keywords

Calcium sensitizer Inotropic agents Septic shock Myocardial depression 

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Andrea Morelli
    • 1
  • Stefano De Castro
    • 2
  • Jean-Louis Teboul
    • 3
  • Mervyn Singer
    • 4
  • Monica Rocco
    • 1
  • Giorgio Conti
    • 5
  • Leonardo De Luca
    • 2
  • Emanuele Di Angelantonio
    • 6
  • Alessandra Orecchioni
    • 1
  • Natesa G. Pandian
    • 7
  • Paolo Pietropaoli
    • 1
  1. 1.Department of Anesthesiology and Intensive CareUniversity of Rome La SapienzaRomeItaly
  2. 2.Department of Cardiovascular and Respiratory SciencesUniversity of Rome La SapienzaRomeItaly
  3. 3.Service de Reanimation MedicaleHôpital de Bicêtre, University of Paris XILe Kremlin-BicêtreFrance
  4. 4.Bloomsbury Institute of Intensive Care MedicineUniversity College LondonLondonUK
  5. 5.Department of Anesthesiology and Intensive CareCatholic University of RomeRomeItaly
  6. 6.Department of Internal MedicineUniversity of Rome La SapienzaRomeItaly
  7. 7.New England Medical CenterTufts UniversityBostonUSA