Intensive Care Medicine

, Volume 32, Issue 3, pp 349–360

Organ dysfunction during sepsis


    • Department of Intensive Care MedicineChelsea and Westminster Hospital
  • Timothy W. Evans
    • Department of Intensive Care Medicine, Royal Brompton HospitalImperial College School of Medicine
Seminal Study in Intensive Care

DOI: 10.1007/s00134-005-0038-9

Cite this article as:
Singh, S. & Evans, T.W. Intensive Care Med (2006) 32: 349. doi:10.1007/s00134-005-0038-9



Multiple organ dysfunction syndrome is the commonest reason for sepsis-associated mortality.


In the 40 years since it was first described understanding of its pathophysiology has improved, and novel methodologies for monitoring and severity of illness scoring have emerged. These, together with the development of systematic strategies for managing organ dysfunction in sepsis, and potentially effective new therapeutic interventions, should assist in reducing sepsis-associated mortality.


These historical developments are discussed, and the reader is directed to these references for further guidance.


Multiple organ dysfunction syndromeSepsisMicrovascular dysfunctionCytopathic hypoxiaBioenergetic failureScoring system

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© Springer-Verlag 2005