Intensive Care Medicine

, Volume 31, Issue 1, pp 56–63

Post-ICU mortality in critically ill infected patients: an international study

  • Élie Azoulay
  • Corinne Alberti
  • Isabelle Legendre
  • Christian Brun Buisson
  • Jean Roger Le Gall
  • for the European Sepsis Group
Original

DOI: 10.1007/s00134-004-2484-1

Cite this article as:
Azoulay, É., Alberti, C., Legendre, I. et al. Intensive Care Med (2005) 31: 56. doi:10.1007/s00134-004-2484-1

Abstract

Objective

To determine the incidence and risk factors for post-ICU mortality in patients with infection.

Design and setting

International observational cohort study including 28 ICUs in eight countries.

Patients

All 1,872 patients discharged alive from the ICU over a 1-year period were screened for infection at ICU admission and daily throughout the ICU stay. Outcomes at ICU and hospital discharge were recorded.

Measurements and results

Post-ICU death occurred in 195 (10.4%) patients and was associated in the multivariable analysis with age, chronic respiratory failure, immunosuppression, cirrhosis, Simplified Acute Physiology Score II on the first day with infection, and LOD score at ICU discharge. Post-ICU death was more common among medical patients and patients with hospital-acquired infection or microbiologically documented infection and was less common in patients with pneumonia.

Conclusions

Post-ICU death in patients with infection was within previously reported ranges in overall ICU populations. The main risk factors were patient and infection characteristics, severity at ICU admission, and persistent organ dysfunction at ICU discharge. Further interventions such as further ICU management, discharge to a step-down unit, or follow-up by intensivists on the ward should be evaluated in patients with a high risk of post-ICU mortality

Keywords

SepsisInfectionPost-ICU mortalityIntensive careOutcomeMulticenter

Supplementary material

Appendix: Investigators

supp.pdf (30 kb)
(PDF 30 KB)

Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • Élie Azoulay
    • 1
  • Corinne Alberti
    • 2
  • Isabelle Legendre
    • 2
  • Christian Brun Buisson
    • 3
  • Jean Roger Le Gall
    • 1
  • for the European Sepsis Group
  1. 1.Intensive Care Unit, Saint-Louis HospitalParis 7 UniversityParisFrance
  2. 2.Unit of Clinical Epidemiology, Robert Debré HospitalParis 7 UniversityParisFrance
  3. 3.Intensive Care UnitHenri-Mondor HospitalCréteilFrance