Dexamethasone decreases neurological sequelae and caspase activity
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To evaluate the use of dexamethasone in a model of meningitis-induced brain injury. Changes in neurobehavioral performance were the primary outcome variables. Changes in caspase activation and markers of neuronal injury were the secondary outcome variables.
Randomized, prospective animal study.
University research laboratory.
Male Wistar rats.
Animals underwent a basilar cistern injection of either placebo or a suspension of Group B Streptococcus. Sixteen hours after inoculation, animals were randomized and received either dexamethasone or placebo in addition to antibiotics. Neurobehavioral performance and biological markers of brain injury were assessed at 3 days and 9 days after randomization. In a second experiment, caspase 1 and 3 were evaluated at 6 h, 24 h, and 72 h after dexamethasone administration.
Measurements and main results
Neurobehavioral performance at 3 days and 9 days was significantly improved in the dexamethasone group. Serum C-tau and cerebral edema were decreased after 3 days of dexamethasone treatment. Dexamethasone decreased Caspase 3 activation in meningitic animals.
These findings demonstrate that dexamethasone decreases acute brain injury in a rat model of bacterial meningitis as measured by preservation of neurobehavioral performance.
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- Dexamethasone decreases neurological sequelae and caspase activity
Intensive Care Medicine
Volume 31, Issue 1 , pp 146-150
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- Brain injury
- Neurobehavioral performance
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- Author Affiliations
- 1. Division of Critical Care Medicine, The Floating Hospital for Children, 750 Washington St, NEMC#093, Boston 02111, Mass., USA
- 2. Department of Pediatrics, Section of Critical Care Medicine, Sacramento, Calif., USA
- 3. Professor of Neuropathology, University of Cincinnati, Cincinnati, Ohio, USA
- 4. Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio, USA
- 5. Division of Critical Care Medicine, Children’s Hospital Medical Center and the Children’s Hospital Research Foundation, Cincinnati, Ohio, USA