RETRACTED ARTICLE: Influence of different volume replacement strategies on inflammation and endothelial activation in the elderly undergoing major abdominal surgery
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- Boldt, J., Ducke, M., Kumle, B. et al. Intensive Care Med (2004) 30: 416. doi:10.1007/s00134-003-2110-7
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Adequate restoration of intravascular volume remains an important maneuver in the management of the surgical patient. Influence of different volume replacement regimens on inflammation/endothelial activation in elderly surgical patients was assessed.
Prospective, randomized study.
Surgical intensive care unit of a university-affiliated hospital.
Sixty-six patients >65 years undergoing major abdominal surgery.
Ringer’s lactate (RL; n=22), normal saline solution (NS; n=22) or a low-molecular HES (mean molecular weight 130 kD) with a low degree of substitution (0.4; HES 130/0.4; n=22) were administered after induction of anesthesia until the 1st postoperative day (POD) to keep central venous pressure between 8–12 mmHg.
Measurements and results
C-reactive protein, interleukins (IL-6, IL-8), adhesion molecules [endothelial leukocyte adhesion molecule-1 (ELAM-1) and intercellular adhesion molecule-1 (ICAM-1)] were measured prior to volume therapy at the end of surgery, 5 h after surgery and at the morning of the 1st POD. RL patients received 10,150±1,660 ml of RL, NS patients 10,220±1,770 ml of NS and the HES-treated group 2,850±300 ml of HES 130/0.4 and 2,810±350 ml of RL. Hemodynamics were similar in all groups. CRP, IL-6 and IL-8 plasma levels increased significantly higher in both crystalloid groups (IL-6 in the NS group: increase to 407±33 pg/ml; RL: increase to 377±35 pg/dl) than in the HES-130 treated group (IL-6: increase to 197±20 pg/dl). Plasma levels of ELAM-1 and ICAM remained almost unchanged in the HES 130-, but significantly increased in the RL- and NS-treated patients.
In elderly patients, markers of inflammation and endothelial injury and activation were significantly higher after crystalloid- than after HES 130/0.4-based volume replacement regimens.