Intensive Care Medicine

, Volume 30, Issue 3, pp 506–509

Measurement of indocyanine green plasma disappearance rate by two different dosages

  • Samir G. Sakka
  • Heiko Koeck
  • Andreas Meier-Hellmann
Brief Report

DOI: 10.1007/s00134-003-2091-6

Cite this article as:
Sakka, S.G., Koeck, H. & Meier-Hellmann, A. Intensive Care Med (2004) 30: 506. doi:10.1007/s00134-003-2091-6



While using a transcutaneous system for assessment of liver function by indocyanine green plasma disappearance rate (ICG-PDR) in critically ill patients, we compared the agreement between ICG-PDR obtained by the recommended standard ICG dosage (0.5 mg/kg) and a reduced dosage (0.25 mg/kg).


Clinical study.


Intensive care unit of a university hospital.


Critically ill patients (n=16, 5 female, 11 male) who underwent liver function monitoring by ICG-PDR for clinical indication.

Measurements and results

We analyzed 31 pairs of ICG-PDR measurements by applying the recommended dosage (0.5 mg/kg, ICG-PDR0.5) and a reduced dosage (0.25 mg/kg, ICG-PDR0.25). For each comparative measurement either first 0.5 mg/kg or 0.25 mg/kg of ICG was injected in a random fashion and followed by the corresponding dosage 60 min later. All patients were sedated and mechanically ventilated via a tracheal tube. Each patient was monitored by an ICG finger clip which was connected to a liver function monitoring system (LiMon, Pulsion Medical Systems, Germany). ICG-PDR0.25 was 2.7–25.0 %/min and ICG-PDR0.5 4.5–24.5 %/min, respectively. Linear regression analysis revealed ICG-PDR0.25=1.13·ICG-PDR0.5−0.66 %/min (r=0.95, p<0.0001) with a mean bias 1.0 %/min (standard deviation 2.5 %/min). The 15 min residual rates were also highly correlated (r=0.92, p<0.0001) with a mean bias of 0.3%.


A reduced dosage of ICG (0.25 mg/kg) is sufficiently accurate for transcutaneous measurement of ICG-PDR in critically ill patients.


Organ functionIndocyanine greenPlasma disappearance rateCritically ill patients

Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • Samir G. Sakka
    • 1
  • Heiko Koeck
    • 1
  • Andreas Meier-Hellmann
    • 2
  1. 1.Department of Anesthesiology and Intensive Care MedicineFriedrich-Schiller-University of JenaJenaGermany
  2. 2.Department of Anesthesiology and Intensive Care MedicineHELIOS-KlinikumErfurtGermany