Intensive Care Medicine

, Volume 27, Issue 12, pp 1931–1936

Effects of hemorrhage on gastrointestinal oxygenation

  • Arnaldo Dubin
  • Elisa Estenssoro
  • Gastón Murias
  • Héctor Canales
  • Pablo Sottile
  • Julio Badie
  • Marcelo Barán
  • Fernando Pálizas
  • Mercedes Laporte
  • Mariana Rivas Díaz
Experimental

DOI: 10.1007/s00134-001-1138-9

Cite this article as:
Dubin, A., Estenssoro, E., Murias, G. et al. Intensive Care Med (2001) 27: 1931. doi:10.1007/s00134-001-1138-9

Abstract.

Objectives: (1) To demonstrate that metabolic parameters are better indicators of tissue hypoxia than regional and whole oxygen consumption (VO2). (2) To compare intramucosal pH (pHi) in different gastrointestinal segments. Design: Prospective, interventional study. Setting: Research laboratory at a university center. Subjects: Fourteen anesthetized, mechanically ventilated dogs. Interventions: Twenty milliliters per kilogram bleeding. Measurements and main results: We placed pulmonary, aortic and mesenteric venous catheters, and an electromagnetic flow probe in the superior mesenteric artery, and gastric, jejunal and ileal tonometers to measure flows, arterial and venous blood gases and lactate, and intramucosal PCO2. We calculated systemic and intestinal oxygen transport (DO2) and consumption (VO2), pHi and arterial minus intramucosal PCO2 (ΔPCO2). Then, we bled the dogs and repeated the measurements after 30 min. Systemic and intestinal DO2 fell (26.0±7.3 versus 8.9±2.6 and 71.9±17.3 versus 24.6±9.6 ml/min per kg, respectively, p<0.0001). Systemic and intestinal VO2 remained unchanged (5.5±1.3 versus 5.4±1.3 and 15.7±5.0 versus 14.9±5.3 ml/min per kg, respectively). Gastric, jejunal and ileal pHi (7.13±0.11 versus 6.96±0.17, 7.18±0.06 versus 6.97±0.15, 7.12±0.11 versus 6.94±0.14, p<0.05) and ΔPCO2 (21±13 versus 35±23, 15±5 versus 33±16, 23±17 versus 38±20, p<0.05) changed accordingly. Arterial and mesenteric venous lactate and their difference, rose significantly (1.7±0.9 versus 3.7±1.4 and 1.8±0.8 versus 4.3±1.5 mmol/l, 0.1±0.6 versus 0.6±0.7 mmol/l, p<0.05). Conclusions: During hemorrhage, systemic and intestinal VO2 remained stable. However, hyperlactatemia and intramucosal acidosis evidenced anaerobic metabolism. pHi changes paralleled in the three intestinal segments.

Intramucosal pH Tonometry Shock Oxygen consumption Oxygen delivery Lactate

Copyright information

© Springer-Verlag 2001

Authors and Affiliations

  • Arnaldo Dubin
    • 1
  • Elisa Estenssoro
    • 1
  • Gastón Murias
    • 1
  • Héctor Canales
    • 1
  • Pablo Sottile
    • 1
  • Julio Badie
    • 1
  • Marcelo Barán
    • 1
  • Fernando Pálizas
    • 1
  • Mercedes Laporte
    • 1
  • Mariana Rivas Díaz
    • 1
  1. 1.Cátedra de Farmacología, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, calle 42 No 577, (1900) La PlataArgentina