Intensive Care Medicine

, Volume 27, Issue 11, pp 1729–1736

Complication profiles of adult asthmatics requiring paralysis during mechanical ventilation

  • Frédéric Adnet
  • Ghislain Dhissi
  • Stephen W. Borron
  • Michel Galinski
  • Fatima Rayeh
  • Michel Cupa
  • Jean Pourriat
  • Frédéric Lapostolle
Original

DOI: 10.1007/s00134-001-1112-6

Cite this article as:
Adnet, F., Dhissi, G., Borron, S.W. et al. Intensive Care Med (2001) 27: 1729. doi:10.1007/s00134-001-1112-6

Abstract.

Objective: To assess the characteristics and the incidence of morbidity of intubated asthmatic patients who received long-term paralysis. Design: Retrospective cohort study. Setting: Five intensive care units (ICUs) in Paris and the surrounding suburbs. Patients and participants: The NMB group consisted of patients who received neuromuscular blocking agents for more than 12 h (NMB group) versus sedation alone (SED). Interventions: None. Measurements and results: The incidence of post-extubation muscle weakness and/or myopathy was 18% in the NMB group compared to 2% in the SED group (p=0.01). The occurrence of ventilator-associated pneumonia was higher in the NMB group (42% versus 4%; p<0.0001). The duration of ICU stay and of mechanical ventilation were significantly greater in the NMB group. Multiple logistic regression analysis showed that inclusion in the NMB group was the only independent predictor of the presence of the overall morbidity [odds ratio 6.4 (2.09; 19.64)]. Conclusion: While greater initial severity of respiratory compromise in the NMB group may explain part of the difference, use of NMB agents appears to be strongly related to the presence of significant complications among mechanically-ventilated asthmatic patients.

Paralysis Morbidity Mortality Mechanical ventilation Near fatal asthma

Copyright information

© Springer-Verlag 2001

Authors and Affiliations

  • Frédéric Adnet
    • 1
  • Ghislain Dhissi
    • 1
  • Stephen W. Borron
    • 2
  • Michel Galinski
    • 3
  • Fatima Rayeh
    • 4
  • Michel Cupa
    • 1
  • Jean Pourriat
    • 5
  • Frédéric Lapostolle
    • 1
  1. 1.SAMU 93, Hôpital Avicenne, Université Paris XIII, 93009 Bobigny CedexFrance
  2. 2.Department of Emergency Medicine, George Washington University Hospital, Washington DC 20037, USAUSA
  3. 3.Service d'Anesthésie-Réanimation, Hôpital Ambroise Paré, 92130 Boulogne BillancourtFrance
  4. 4.Service de Réanimation, Hôpital de Poitiers, 86021 Poitiers CedexFrance
  5. 5.Service de Réanimation, Hôpital Jean Verdier, 93140 BondyFrance