Article

Bulletin of Environmental Contamination and Toxicology

, Volume 89, Issue 4, pp 693-698

First online:

Lead Bone Toxicity in Growing Rats Exposed to Chronic Intermittent Hypoxia

  • María I. ContiAffiliated withDepartment of Physiology, University of Buenos Aires Email author 
  • , Clarisa BozziniAffiliated withDepartment of Physiology, University of Buenos Aires
  • , Graciela B. FacorroAffiliated withDepartment of Physics, University of Buenos Aires
  • , Ching M. LeeAffiliated withDepartment of Physiology, University of Buenos Aires
  • , Patricia M. MandalunisAffiliated withDepartment of Histology and Embryology, Faculty of Dentistry, University of Buenos Aires
  • , Lidia L. PiehlAffiliated withDepartment of Physics, University of Buenos Aires
  • , Adriana E. PiñeiroAffiliated withDepartment of Toxicology and Legal Chemistry, Faculty of Pharmacy and Biochemistry, University of Buenos Aires
  • , Antonela R. TerrizziAffiliated withDepartment of Physiology, University of Buenos Aires
  • , María P. MartínezAffiliated withDepartment of Physiology, University of Buenos Aires

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Abstract

Lead chronic intoxication under hypoxic conditions revealed growth retardation in growing rats and damages on femoral and mandibular bones that predispose to fractures. These findings aimed us to investigate if bone material and geometric properties, bone mass in terms of histomorphometry or antioxidant capacity are also impaired in such experimental model. Combined treatments significantly reduced hemimandible cross sectional geometry and intrinsic stiffness (−16 % and −34 %); tibia and hemimandible bone volume (−45 % and −40 %) and growth plate cartilage thickness (−19 %). These results show a previously unreported toxic effect of lead on mandible however, longer studies should be necessary to evaluate if an adaptation of bone architecture to maintain structural properties may occur and if the oxidative stress can be identified as the primary contributory agent in the pathogenesis of lead poisoning.

Keywords

Lead poisoning Intermittent hypoxia Bone biomechanics Bone histomorphometry Oxidative stress