Bulletin of Environmental Contamination and Toxicology

, Volume 89, Issue 4, pp 693–698

Lead Bone Toxicity in Growing Rats Exposed to Chronic Intermittent Hypoxia

Authors

    • Department of PhysiologyUniversity of Buenos Aires
  • Clarisa Bozzini
    • Department of PhysiologyUniversity of Buenos Aires
  • Graciela B. Facorro
    • Department of PhysicsUniversity of Buenos Aires
  • Ching M. Lee
    • Department of PhysiologyUniversity of Buenos Aires
  • Patricia M. Mandalunis
    • Department of Histology and Embryology, Faculty of DentistryUniversity of Buenos Aires
  • Lidia L. Piehl
    • Department of PhysicsUniversity of Buenos Aires
  • Adriana E. Piñeiro
    • Department of Toxicology and Legal Chemistry, Faculty of Pharmacy and BiochemistryUniversity of Buenos Aires
  • Antonela R. Terrizzi
    • Department of PhysiologyUniversity of Buenos Aires
  • María P. Martínez
    • Department of PhysiologyUniversity of Buenos Aires
Article

DOI: 10.1007/s00128-012-0753-1

Cite this article as:
Conti, M.I., Bozzini, C., Facorro, G.B. et al. Bull Environ Contam Toxicol (2012) 89: 693. doi:10.1007/s00128-012-0753-1

Abstract

Lead chronic intoxication under hypoxic conditions revealed growth retardation in growing rats and damages on femoral and mandibular bones that predispose to fractures. These findings aimed us to investigate if bone material and geometric properties, bone mass in terms of histomorphometry or antioxidant capacity are also impaired in such experimental model. Combined treatments significantly reduced hemimandible cross sectional geometry and intrinsic stiffness (−16 % and −34 %); tibia and hemimandible bone volume (−45 % and −40 %) and growth plate cartilage thickness (−19 %). These results show a previously unreported toxic effect of lead on mandible however, longer studies should be necessary to evaluate if an adaptation of bone architecture to maintain structural properties may occur and if the oxidative stress can be identified as the primary contributory agent in the pathogenesis of lead poisoning.

Keywords

Lead poisoningIntermittent hypoxiaBone biomechanicsBone histomorphometryOxidative stress

Copyright information

© Springer Science+Business Media, LLC 2012