3-Hydroxy 3-Methylglutaryl Coenzyme A Reductase: a New Biomarker of Fish Exposure to Water Pollution
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- Pallottini, V., Scalici, M., Gibertini, G. et al. Bull Environ Contam Toxicol (2010) 85: 381. doi:10.1007/s00128-010-0095-9
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The aim of this study was to identify a new putative biomarker in Salmo trutta exposed to water pollution. Variations in the levels of hepatic 3-hydroxy 3-methylglutaryl Coenzyme A reductase (HMG-CoAR), the rate-limiting enzyme of cholesterol biosynthesis, were compared to heat shock protein 70 and hypoxia inducible factor α, biomarkers of pollution exposure and lowered O2, respectively. The results confirm that HMG-CoAR levels increase in polluted water irrespective of water temperature or O2 content, indicating that HMG-CoAR could be used as a specific biomarker for water pollution.