Bulletin of Environmental Contamination and Toxicology

, Volume 85, Issue 4, pp 381–384

3-Hydroxy 3-Methylglutaryl Coenzyme A Reductase: a New Biomarker of Fish Exposure to Water Pollution

  • Valentina Pallottini
  • Massimiliano Scalici
  • Giancarlo Gibertini
  • Maria Marino
  • Anna Trentalance
Article

DOI: 10.1007/s00128-010-0095-9

Cite this article as:
Pallottini, V., Scalici, M., Gibertini, G. et al. Bull Environ Contam Toxicol (2010) 85: 381. doi:10.1007/s00128-010-0095-9

Abstract

The aim of this study was to identify a new putative biomarker in Salmo trutta exposed to water pollution. Variations in the levels of hepatic 3-hydroxy 3-methylglutaryl Coenzyme A reductase (HMG-CoAR), the rate-limiting enzyme of cholesterol biosynthesis, were compared to heat shock protein 70 and hypoxia inducible factor α, biomarkers of pollution exposure and lowered O2, respectively. The results confirm that HMG-CoAR levels increase in polluted water irrespective of water temperature or O2 content, indicating that HMG-CoAR could be used as a specific biomarker for water pollution.

Keywords

HMG-CoA reductaseHIF-1αSalmo truttaWater pollution

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Valentina Pallottini
    • 1
  • Massimiliano Scalici
    • 1
  • Giancarlo Gibertini
    • 1
  • Maria Marino
    • 1
  • Anna Trentalance
    • 1
  1. 1.Department of BiologyUniversity of Roma TreRomeItaly