Polybrominated Diphenyl Ethers in Human Serum and Sperm Quality

  • K. Akutsu
  • S. Takatori
  • S. Nozawa
  • M. Yoshiike
  • H. Nakazawa
  • K. Hayakawa
  • T. Makino
  • T. Iwamoto
Article

DOI: 10.1007/s00128-008-9370-4

Cite this article as:
Akutsu, K., Takatori, S., Nozawa, S. et al. Bull Environ Contam Toxicol (2008) 80: 345. doi:10.1007/s00128-008-9370-4

Abstract

Polybrominated diphenyl ethers (PBDEs) are widely used flame retardants; currently, they are identified as ubiquitous environmental contaminants. Several studies indicate that PBDEs might affect male fertility. We present the results of a pilot study on the relationship between human serum PBDEs and sperm quality. The PBDE levels in Japan are comparable to those found in European countries. Strong inverse correlations were observed between the serum concentration of 2,2′,4,4′,5,5′-hexabromodiphenyl ether and sperm concentration (r = −0.841, p = 0.002) and testis size (r = −0.764, p = 0.01). Extensive studies on the relationship between PBDEs and sperm quality are required.

Keywords

Polybrominated diphenyl ethers Flame retardants Human serum Sperm 

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • K. Akutsu
    • 1
    • 2
  • S. Takatori
    • 1
  • S. Nozawa
    • 3
  • M. Yoshiike
    • 3
  • H. Nakazawa
    • 4
  • K. Hayakawa
    • 2
  • T. Makino
    • 5
  • T. Iwamoto
    • 3
    • 6
  1. 1.Division of Food ChemistryOsaka Prefectural Institute of Public HealthHigashinari-kuJapan
  2. 2.Graduate School of Natural Science and TechnologyKanazawa UniversityKanazawaJapan
  3. 3.Department of UrologySt. Marianna University School of MedicineKawasakiJapan
  4. 4.Department of Analytical ChemistryHoshi UniversityShinagawa-ku, TokyoJapan
  5. 5.Department of Obstetrics and Gynecology, School of MedicineTokai UniversityIseharaJapan
  6. 6.Center for Infertility and IVFInternational University of Health and WelfareOhtawaraJapan