Social Psychiatry and Psychiatric Epidemiology

, Volume 33, Issue 8, pp 387–392

Incidence of dementia and cognitive decline in over-75s in Cambridge: overview of cohort study

  • E. S. Paykel
  • F. A. Huppert
  • C. Brayne
ORIGINAL PAPER

DOI: 10.1007/s001270050070

Cite this article as:
Paykel, E., Huppert, F. & Brayne, C. Soc Psychiatry Psychiatr Epidemiol (1998) 33: 387. doi:10.1007/s001270050070

Abstract

This paper summarises the methods and some of the findings of a large cohort study of dementia and cognitive decline in subjects aged over 75 years in Cambridge, particularly regarding the incidence wave. From a sample of 1968 subjects previously studied in a prevalence study in 1985–1987, survivors were restudied at 2.4 years, in a two-stage design employing the Mini; Mental State Examination (MMSE) and the Cambridge Examination for Mental Disorders of the Elderly (CAMDEX). High incidence rates of dementia were found, which rose steeply with age, particularly for Alzheimer's disease. New minimal dementia and milder cognitive impairment were also common. Cognitive decline on the MMSE showed a near normal, non-bimodal distribution. The sample has since been restudied at intervals for a total of up to 9 years to document longitudinal cognitive change. Brains have been obtained for post mortem neuropathological and molecular biological study, particularly of the early sequential changes associated with cognitive decline and dementia.

Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • E. S. Paykel
    • 1
  • F. A. Huppert
    • 1
  • C. Brayne
    • 2
  1. 1.Department of Psychiatry, University of Cambridge, Box 189 Addenbrooke's Hospital, Cambridge CB2 2QQ, UKGB
  2. 2.Institute of Public Health, University of Cambridge, Forvie Site, Addenbrooke's Hospital, Cambridge CB2 2QQ, UKGB