Social Psychiatry and Psychiatric Epidemiology

, Volume 33, Issue 1, pp 21–26

Apolipoprotein E phenotype is not related to late-life depression in a population-based sample

  • B. Schmand
  • C. Hooijer
  • C. Jonker
  • J. Lindeboom
  • L. M. Havekes
ORIGINAL PAPER

DOI: 10.1007/s001270050017

Cite this article as:
Schmand, B., Hooijer, C., Jonker, C. et al. Soc Psychiatry Psychiatr Epidemiol (1997) 33: 21. doi:10.1007/s001270050017

Abstract

Apolipoprotein E (ApoE) allele frequencies were examined in a population-based sample (n=475; age range 65–84 years; Amsterdam Study of the Elderly). The relation of ApoE ε4 with dementia and with various types of late-life depression was studied. Depression was measured with the Geriatric Mental State schedule. Dementia was diagnosed by DSM-III-R criteria. It was expected that ApoE ε4 allele frequencies would be elevated not only in Alzheimer's disease and dementia in general, but also in first episode, late-life depression accompanied by subtle cognitive impairment (possibly organic depression). However, the results indicated that ε4 allele frequency is related to (family history of) dementia and cognitive impairment, but not to possibly organic depression. The main predictor of late-life depression is an episode of psychiatric problems before the age of 65 years.

Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • B. Schmand
    • 1
  • C. Hooijer
    • 1
  • C. Jonker
    • 1
  • J. Lindeboom
    • 1
  • L. M. Havekes
    • 5
  1. 1.AMSTEL project, Department of Psychiatry and the Institute of Extramural Health Research (EMGO), Free University, Amsterdam, The NetherlandsNL
  2. 2.Slotervaart Hospital Amsterdam, The NetherlandsNL
  3. 3.Van Foreest Center, Heiloo, The NetherlandsNL
  4. 4.Department of Medical Psychology, Free University, Amsterdam, The NetherlandsNL
  5. 5.TNO-PG Gaubius Laboratory, Leiden, The NetherlandsNL
  6. 6.AMSTEL project, Faculteit SCW, DeBoelelaan 1081c, 1081 HV Amsterdam, The NetherlandsNL