Social Psychiatry and Psychiatric Epidemiology

, Volume 46, Issue 12, pp 1325–1330

Predictors of relapse in Chinese schizophrenia patients: a prospective, multi-center study

Authors

  • Yu-Tao Xiang
    • Beijing Anding Hospital, Capital Medical University
    • Department of PsychiatryChinese University of Hong Kong
    • Beijing Anding Hospital, Capital Medical University
    • Laboratory of Clinical PsychopharmacologyBeijing Anding Hospital
  • Yong-Zhen Weng
    • Beijing Anding Hospital, Capital Medical University
  • Qi-Jing Bo
    • Beijing Anding Hospital, Capital Medical University
  • Helen F. K. Chiu
    • Department of PsychiatryChinese University of Hong Kong
  • Sandra S. M. Chan
    • Department of PsychiatryChinese University of Hong Kong
  • Edwin H. M. Lee
    • Department of PsychiatryChinese University of Hong Kong
  • Gabor S. Ungvari
    • School of Psychiatry & Clinical Neurosciences, University of Western Australia
Original Paper

DOI: 10.1007/s00127-010-0304-1

Cite this article as:
Xiang, Y., Wang, C., Weng, Y. et al. Soc Psychiatry Psychiatr Epidemiol (2011) 46: 1325. doi:10.1007/s00127-010-0304-1

Abstract

Objective

Relapse prevention is the main goal of maintenance treatment in schizophrenia. This study aimed to determine the rate and the socio-demographic and clinical predictors of relapse in Chinese schizophrenia patients following treatment of the acute phase of the illness.

Methods

In a multi-center, randomized, controlled, longitudinal study, 404 patients with schizophrenia who were clinically stabilized following an acute episode were randomly assigned to either the maintenance (i.e., initial optimal therapeutic doses continued throughout the study) or the dose-reduction group (i.e., initial optimal therapeutic doses continued for 4 or 26 weeks followed by a 50% dose reduction that was maintained until the end of the study). Participants were interviewed at entry using standardized assessment instruments, and followed up for 12–26 months.

Results

In univariate analyses, relapse was significantly associated with the membership of the dose-reduction group, poor medication adherence, and having a diagnosis of the paranoid type of schizophrenia. In Cox proportional-hazards regression analysis the membership of the dose-reduction group, poorer medication adherence, more severe drug-induced side effects and prominent paranoid symptoms independently predicted a higher risk of relapse.

Conclusion

The study confirmed the importance of maintenance medication in preventing relapse in Chinese schizophrenia patients underscoring the risk of relapse associated with lack of treatment adherence, severe side effects and the patients’ paranoid attitude. Socio-demographic characteristics were not associated with relapse in Chinese schizophrenia patients. Potential residual confounding caused by unmeasured variables should be fully considered in future studies.

Keywords

SchizophreniaMaintenance treatmentRelapseParanoidChina

Copyright information

© Springer-Verlag 2010