A choice of death – the signal-transduction of immune-mediated beta-cell apoptosis
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- Eizirik, D. & Mandrup-Poulsen, T. Diabetologia (2001) 44: 2115. doi:10.1007/s001250100021
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Apoptosis is likely to be the main form of beta-cell death in immune-mediated diabetes mellitus in rodents and possibly in humans. Clarification of the regulation of beta-cell death could indicate novel sites for therapeutic intervention in Type I (insulin-dependent) diabetes mellitus. We review the molecular effectors and signal transduction of immune-mediated beta-cell apoptosis.