, Volume 44, Issue 12, pp 2115–2133

A choice of death – the signal-transduction of immune-mediated beta-cell apoptosis

  • D. L. Eizirik
  • T. Mandrup-Poulsen

DOI: 10.1007/s001250100021

Cite this article as:
Eizirik, D. & Mandrup-Poulsen, T. Diabetologia (2001) 44: 2115. doi:10.1007/s001250100021


Apoptosis is likely to be the main form of beta-cell death in immune-mediated diabetes mellitus in rodents and possibly in humans. Clarification of the regulation of beta-cell death could indicate novel sites for therapeutic intervention in Type I (insulin-dependent) diabetes mellitus. We review the molecular effectors and signal transduction of immune-mediated beta-cell apoptosis.

Keywords Beta cell apoptosis interleukin-1 interferon-γ nitric oxide diabetes mellitus. 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2001

Authors and Affiliations

  • D. L. Eizirik
    • 1
  • T. Mandrup-Poulsen
    • 2
  1. 1.Gene Expression Unit, Diabetes Research Center, Vrije Universiteit Brussel, Brussels, BelgiumBE
  2. 2.Steno Diabetes Center, Gentofte, DenmarkDK