, Volume 44, Issue 12, pp 2115-2133

A choice of death – the signal-transduction of immune-mediated beta-cell apoptosis


Apoptosis is likely to be the main form of beta-cell death in immune-mediated diabetes mellitus in rodents and possibly in humans. Clarification of the regulation of beta-cell death could indicate novel sites for therapeutic intervention in Type I (insulin-dependent) diabetes mellitus. We review the molecular effectors and signal transduction of immune-mediated beta-cell apoptosis.

Received: 18 June 2001 and in revised form: 6 August 2001