A choice of death – the signal-transduction of immune-mediated beta-cell apoptosis
Apoptosis is likely to be the main form of beta-cell death in immune-mediated diabetes mellitus in rodents and possibly in humans. Clarification of the regulation of beta-cell death could indicate novel sites for therapeutic intervention in Type I (insulin-dependent) diabetes mellitus. We review the molecular effectors and signal transduction of immune-mediated beta-cell apoptosis.
- A choice of death – the signal-transduction of immune-mediated beta-cell apoptosis
Volume 44, Issue 12 , pp 2115-2133
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- Keywords Beta cell
- nitric oxide
- diabetes mellitus.
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