Diabetologia

, Volume 44, Issue 6, pp 706–712

Oxidative stress could precede endothelial dysfunction and insulin resistance in Indian Mauritians with impaired glucose metabolism

  • N. K. Gopaul
  • M. D. Manraj
  • A. Hébé
  • S. Lee Kwai Yan
  • A. Johnston
  • M. J. Carrier
  • E. E. Änggård
Article

DOI: 10.1007/s001250051679

Cite this article as:
Gopaul, N., Manraj, M., Hébé, A. et al. Diabetologia (2001) 44: 706. doi:10.1007/s001250051679
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Abstract

Aims/hypothesis. To measure oxidative stress, endothelial dysfunction and insulin resistance in Indian Mauritians at different stages of development of Type II (non-insulin-dependent) diabetes mellitus. Methods. Plasma total 8-epi-PGF2α, an indicator of oxidative stress, was determined in age-matched subjects with normal glucose metabolism (n = 39), impaired glucose tolerance (n = 14), newly diagnosed diabetes (n = 8) and established diabetes (n = 14). Plasma glucose and insulin were measured at baseline and 2 h following an oral glucose tolerance test. Endothelial function was assessed by non-invasive digital pulse wave photoplethysmography. Results. Plasma 8-epi-PGF2α increased in subjects with impaired glucose tolerance (p < 0.05) compared with control subjects, and was even higher in newly diagnosed diabetic patients (p < 0.01) and established (p < 0.01) diabetic patients. A tendency towards reduced endothelial function in subjects with impaired glucose tolerance became significant in patients with newly diagnosed and established diabetes (p < 0.01), and was correlated with 8-epi-PGF2α (r = 0.36, p < 0.01). Insulin resistance (homeostasis model assessment) did not change in subjects with impaired glucose tolerance compared with control subjects, but increased in newly diagnosed (p < 0.01) and established (p < 0.001) diabetic subjects. The 8-epi-PGF2α was correlated with fasting glucose (r = 0.50, p < 0.001), triglycerides (r = 0.40, p < 0.001) and insulin resistance (r = 0.35, p < 0.001). Conclusion/interpretation. Oxidant stress is an early event in the evolution of Type II diabetes and could precede the development of endothelial dysfunction and insulin resistance. [Diabetologia (2001) 44: 706–712

Keywords Type II diabetes F2-isoprostanes oxidative stress endothelial dysfunction insulin resistance 
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© Springer-Verlag Berlin Heidelberg 2001

Authors and Affiliations

  • N. K. Gopaul
    • 1
  • M. D. Manraj
    • 2
  • A. Hébé
    • 2
  • S. Lee Kwai Yan
    • 2
  • A. Johnston
    • 3
  • M. J. Carrier
    • 1
  • E. E. Änggård
    • 1
  1. 1.Department of Experimental Therapeutics, William Harvey Research Institute, St. Bartholomew and the Royal London School of Medicine and Dentistry, Queen Mary, London, UKGB
  2. 2.SSR Centre for Medical Studies and Research, University of Mauritius, Moka, MauritiusMU
  3. 3.Clinical Pharmacology, St. Bartholomew and the Royal London School of Medicine and Dentistry, Queen Mary, London, UKGB

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