Diabetologia

, Volume 43, Issue 11, pp 1381–1384

Autoantibodies to ICA12 (SOX-13) are not specific for Type I diabetes

  • H. Steinbrenner
  • T. Lohmann
  • B. Ostendorf
  • W. A. Scherbaum
  • J. Seissler
Short Communication

DOI: 10.1007/s001250051542

Cite this article as:
Steinbrenner, H., Lohmann, T., Ostendorf, B. et al. Diabetologia (2000) 43: 1381. doi:10.1007/s001250051542

Abstract

Aims/hypothesis. The majority of patients with Type I (insulin-dependent) diabetes mellitus has autoantibodies to insulin, glutamic acid decarboxylase and the tyrosine phosphatase-like protein IA-2. Some patients with Type I diabetes, in particular with adult onset diabetes, have, however, only cytoplasmic islet cell antibodies that could be directed to as yet unknown beta cell autoantigens. Recently, one potential antigen, ICA12, was identified as the high mobility group (HMG) box transcription factor SOX-13. Our aim was to evaluate the diagnostic sensitivity and specificity of autoantibodies to SOX-13 for autoimmune diabetes.¶Methods. Full-length SOX-13 was cloned from human brain mRNA, expressed by vitro transcription/translation and used to detect autoantibodies by immunoprecipitation and radioligand assay in patients suffering from autoimmune diabetes or non-organ-specific autoimmune diseases.¶Results. We found SOX-13 antibodies to be present in 11 of 125 (8.8 %) patients with newly diagnosed Type I diabetes and in 3 of 43 (7.0 %) patients with latent autoimmune diabetes in adults. There was no association with age, sex and a particular pattern of diabetes-specific autoantibodies. Similar frequencies of SOX-13 antibodies were found in 84 patients with rheumatic diseases (4.0–11.4 %) and 211 healthy control subjects (5.2 %).¶Conclusions/interpretation. Our data indicate that SOX-13 represents a minor target of autoantibodies in patients with autoimmune diabetes. Because SOX-13 antibodies were found not to be disease-specific, we assume they are not helpful in improving the diagnosis and prediction of Type I diabetes. [Diabetologia (2000) 43: 1381–1384]

Keywords Autoantibodies, autoantigen, ICA12, SOX-13, Type I diabetes.
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Copyright information

© Springer-Verlag Berlin Heidelberg 2000

Authors and Affiliations

  • H. Steinbrenner
    • 1
  • T. Lohmann
    • 2
  • B. Ostendorf
    • 1
  • W. A. Scherbaum
    • 1
  • J. Seissler
    • 1
  1. 1.German Diabetes Research Institute at the University of Duesseldorf, GermanyDE
  2. 2.Department of Medicine III, University of Leipzig, GermanyDE
  3. 3.Department of Rheumatology, University of Duesseldorf, GermanyDE