, Volume 40, Supplement 2, pp S2–S17

The insulin signalling system and the IRS proteins

  • M. F. White

DOI: 10.1007/s001250051387

Cite this article as:
White, M. Diabetologia (1997) 40(Suppl 2): S2. doi:10.1007/s001250051387


During the past few years, the insulin signalling system has emerged as a flexible network of interacting proteins. By utilizing the insulin receptor substrate (IRS)-proteins (IRS-1 and IRS-2), the insulin signal can be amplified or attenuated independently of insulin binding and tyrosine kinase activity, providing an extensible mechanism for signal transmission in multiple cellular backgrounds. By employing IRS-proteins to engage various signalling proteins, the insulin receptor avoids the stoichiometric constraints encountered by receptors which directly recruit SH2-proteins to their autophosphorylation sites. Finally, the shared use of IRS-proteins by multiple receptors is likely to reveal important connections between insulin and other hormones and cytokines which were previously unrecognized, or observed but unexplained. [Diabetologia (1997) 40: S 2–S 17]

Keywords Insulin action insulin signalling insulin receptor substrate proteins signal transduction. 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • M. F. White
    • 1
  1. 1.Research Division, Joslin Diabetes Center and Harvard Medical School, Boston, Massachusetts, USAUS

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