Diabetologia

, Volume 42, Issue 7, pp 793–801

Prevention of Type II diabetes in subjects with impaired glucose tolerance: the Diabetes Prevention Study (DPS) in Finland Study design and 1-year interim report on the feasibility of the lifestyle intervention programme

Study design and 1-year interim report on the feasibility of the lifestyle intervention programme

Authors

  • J. Eriksson
    • National Public Health Institute, Department of Epidemiology and Health Promotion, Diabetes and Genetic Epidemiology Unit, Helsinki, Finland
  • J. Lindström
    • National Public Health Institute, Department of Epidemiology and Health Promotion, Diabetes and Genetic Epidemiology Unit, Helsinki, Finland
  • T. Valle
    • National Public Health Institute, Department of Epidemiology and Health Promotion, Diabetes and Genetic Epidemiology Unit, Helsinki, Finland
  • S. Aunola
    • Social Insurance Institution, Research and Development Centre, Turku, Finland
  • H. Hämäläinen
    • Social Insurance Institution, Research and Development Centre, Turku, Finland
  • P. Ilanne-Parikka
    • Finnish Diabetes Association, The Diabetes Centre, Tampere, Finland
  • S. Keinänen-Kiukaanniemi
    • University of Oulu, Department of Public Health Science and General Practice, Oulu, Finland
  • M. Laakso
    • University of Oulu, Department of Public Health Science and General Practice, Oulu, Finland
  • M. Lauhkonen
    • Institute of Nursing and Health Care, Tampere, Finland
  • P. Lehto
    • Institute of Nursing and Health Care, Tampere, Finland
  • A. Lehtonen
    • University of Turku, Department of Geriatrics, Turku, Finland
  • A. Louheranta
    • University of Kuopio, Department of Clinical Nutrition, Kuopio, Finland
  • M. Mannelin
    • Department of Sports Medicine, Oulu Deaconess Institute, Oulu, Finland
  • V. Martikkala
    • Department of Sports Medicine, Oulu Deaconess Institute, Oulu, Finland
  • M. Rastas
    • Social Insurance Institution, Research and Development Centre, Turku, Finland
  • J. Sundvall
    • National Public Health Institute, Department of Biochemistry, Helsinki, Finland
  • A. Turpeinen
    • University of Kuopio, Department of Clinical Nutrition, Kuopio, Finland
  • T. Viljanen
    • Paavo Nurmi Centre, Turku, Finland
  • M. Uusitupa
    • University of Kuopio, Department of Clinical Nutrition, Kuopio, Finland
  • J. Tuomilehto
    • National Public Health Institute, Department of Epidemiology and Health Promotion, Diabetes and Genetic Epidemiology Unit, Helsinki, Finland
  • on behalf of the Finnish Diabetes Prevention Study Group
Articles, Short communication

DOI: 10.1007/s001250051229

Cite this article as:
Eriksson, J., Lindström, J., Valle, T. et al. Diabetologia (1999) 42: 793. doi:10.1007/s001250051229

Abstract

Aims/hypothesis. The aim of the Diabetes Prevention Study is to assess the efficacy of an intensive diet-exercise programme in preventing or delaying Type II (non-insulin-dependent) diabetes mellitus in subjects with impaired glucose tolerance, to evaluate the effects of the intervention programme on cardiovascular risk factors and to assess the determinants for the progression to diabetes in persons with impaired glucose tolerance. Methods. A total of 523 overweight subjects with impaired glucose tolerance ascertained by two oral glucose tolerance tests were randomised to either a control or intervention group. The control subjects received general information at the start of the trial about the lifestyle changes necessary to prevent diabetes and about annual follow-up visits. The intervention subjects had seven sessions with a nutritionist during the first year and a visit every 3 months thereafter aimed at reducing weight, the intake of saturated fat and increasing the intake of dietary fibre. Intervention subjects were also guided individually to increase their physical activity. Results. During the first year, weight loss in the first 212 study subjects was 4.7 ± 5.5 vs 0.9 ± 4.1 kg in the intervention and control group, respectively (p < 0.001). The plasma glucose concentrations (fasting: 5.9 ± 0.7 vs 6.4 ± 0.8 mmol/l, p < 0.001; and 2-h 7.8 ± 1.8 vs 8.5 ± 2.3 mmol/l, p < 0.05) were significantly lower in the intervention group after the first year of intervention. Favourable changes were also found in blood pressure, serum lipids and anthropometric indices in the intervention group. Conclusion/interpretation. The interim results show the efficacy and feasibility of the lifestyle intervention programme. [Diabetologia (1999) 42: 793–801]

Keywords Type II diabetes mellitus impaired glucose tolerance diet physical activity primary prevention lipids weight obesity glucose blood pressure.

Copyright information

© Springer-Verlag Berlin Heidelberg 1999