Diabetologia

, Volume 40, Issue 3, pp 344–347

Vitamin D, glucose tolerance and insulinaemia in elderly men

  • K. C. R. Baynes
  • B. J. Boucher
  • E. J. M. Feskens
  • D. Kromhout
Rapid communications

DOI: 10.1007/s001250050685

Cite this article as:
Baynes, K., Boucher, B., Feskens, E. et al. Diabetologia (1997) 40: 344. doi:10.1007/s001250050685

Summary

Vitamin D status was assessed in 142 elderly Dutchmen participating in a prospective population-based study of environmental factors in the aetiology of non-insulin-dependent diabetes mellitus. Of the men aged 70–88 years examined between March and May 1990, 39 % were vitamin D depleted. After adjustment for confounding by age, BMI, physical activity, month of sampling, cigarette smoking and alcohol intake the 1-h glucose and area under the glucose curve during a standard 75-g oral glucose tolerance test (OGTT) were inversely associated with the serum concentration of 25-OH vitamin D (r = −0.23, p < 0.01; r = −0.26, p < 0.01, respectively). After excluding newly diagnosed diabetic patients total insulin concentrations during OGTT were also inversely associated with the concentration of 25-OH vitamin D (r = −0.18 to −0.23, p < 0.05). Hypovitaminosis D may be a significant risk factor for glucose intolerance. [Diabetologia (1997) 40: 344–347]

Keywords Insulinglucose tolerancevitamin Delderly.
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Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • K. C. R. Baynes
    • 1
  • B. J. Boucher
    • 1
  • E. J. M. Feskens
    • 2
  • D. Kromhout
    • 2
  1. 1.Cellular Mechanisms Research Group, St. Bartholomew's and The Royal London School of Medicine and Dentistry, Whitechapel, London, UKGB
  2. 2.Department of Chronic Diseases Epidemiology, National Institute of Public Health and Environmental Protection, Bilthoven, The NetherlandsNL