Diabetologia

, Volume 43, Issue 2, pp 242–244

Association of –3826 G Variant in uncoupling protein-1 with increased BMI in overweight Australian women

  • L. K. Heilbronn
  • K. L. Kind
  • E. Pancewicz
  • A. M. Morris
  • M. Noakes
  • P. M. Clifton
Article

DOI: 10.1007/s001250050036

Cite this article as:
Heilbronn, L., Kind, K., Pancewicz, E. et al. Diabetologia (2000) 43: 242. doi:10.1007/s001250050036

Abstract

Aims/hypothesis. To determine whether genetic variation in uncoupling protein-1 (UCP-1) is associated with obesity or obesity-related risk factors in overweight women.¶Methods. We genotyped 526 overweight/obese women (mean body mass index 34.1 kg/m2, range 25.0 to 47.5 kg/m2) for the –3826 AG uncoupling protein-1 polymorphism. Of the 526 women genotyped 144 had fasting blood samples analysed for glucose and lipid measurements.¶Results. The –3826 G allele was found with a frequency of 0.23 and was associated with higher BMI (p = 0.02). A higher frequency of this polymorphism (0.33) was found in subjects with Type II (non-insulin-dependent) diabetes mellitus (p = 0.02), though adjustment for BMI weakened this significance (p = 0.06). The –3826 G variant was associated with increased fasting glucose (p = 0.01). This was, however, a result of a greater proportion of women with Type II diabetes also having the G variant (p = 0.10, adjusted for Type II diabetes). The –3826 G variant of uncoupling protein-1 did not have an effect on other metabolic variables associated with obesity.¶Conclusion/interpretation. In overweight Australian women the –3826 G variant of UCP-1 increased the susceptibility to obesity indicating that UCP-1 could be involved in weight regulation. [Diabetologia (2000) 43: 242–244]

Keywords Uncoupling protein-1, polymorphism, obesity, Type II diabetes.
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Copyright information

© Springer-Verlag Berlin Heidelberg 2000

Authors and Affiliations

  • L. K. Heilbronn
    • 1
  • K. L. Kind
    • 2
  • E. Pancewicz
    • 1
  • A. M. Morris
    • 1
  • M. Noakes
    • 2
  • P. M. Clifton
    • 2
  1. 1. Department of Physiology, University of Adelaide, South AustraliaAU
  2. 2. Commonwealth Scientific Industrial Research Organization (CSIRO) Health Sciences and Nutrition, Adelaide, South AustraliaAU