Diabetologia

, Volume 43, Issue 2, pp 231–234

Comparison of progression of macrovascular diseases after kidney or pancreas and kidney transplantation in diabetic patients with end-stage renal disease

  • G. Biesenbach
  • R. Margreiter
  • A. Königsrainer
  • C. Bösmüller
  • O. Janko
  • P. Brücke
  • C. Gross
  • J Zazgornik
Article

DOI: 10.1007/s001250050034

Cite this article as:
Biesenbach, G., Margreiter, R., Königsrainer, A. et al. Diabetologia (2000) 43: 231. doi:10.1007/s001250050034

Abstract

Aims/hypothesis. The aim of the study was to examine the effect of pancreas-kidney transplantation on the progression of macrovascular diseases in Type I diabetic patients with end-stage renal disease.¶Methods. The progression of cerebrovascular disease, coronary heart disease and peripheral vascular disease in uraemic patients with Type I (insulin-dependent) diabetes mellitus and who had had simultaneous pancreas-kidney transplantation was compared with that of recipients of a kidney transplant alone. Between 1986 and 1998 a total of 11 uraemic diabetic patients received a simultaneous pancreas-kidney transplantation and 10 diabetic patients a kidney transplant alone. All transplants functioned for at least 24 months, the mean observation period was 69 ± 37 compared with 70 ± 33 months in both patient groups. Macroangiopathic diseases were classified in four stages as described earlier.¶Results. In the group with simultaneous pancreas-kidney transplantation progression of cerebrovascular and coronary heart disease was observed in four patients (36 %) and progression of peripheral vascular disease in five subjects (45 %). In the cohort with kidney transplant alone four patients (40 %) showed progression of cerebrovascular and coronary heart disease and five progression of peripheral vascular disease (50 %); the difference is not significant. Mean values of HbA1 c (5.8 ± 0.2 vs 7.5 ± 0.6 %, p < 0.001) and serum triglycerides (1.2 ± 0.4 vs 2.0 ± 1.0 mmol/l, p < 0.05) were significantly lower in the patients with pancreas-kidney transplantation than in the patient group with kidney transplant alone. Serum cholesterol concentrations and blood pressures were similar in both cohorts.¶Conclusion/interpretation. From our results we concluded that pancreas-kidney transplantation reduces risk factors for the development of macroangiopathy but fails to halt progression of macrovascular diseases similar to Type I diabetic patients with kidney transplant alone. [Diabetologia (2000) 43: 231–234]

Keywords Type I diabetes, pancreas-kidney transplantation, macroangiopathic diseases. 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2000

Authors and Affiliations

  • G. Biesenbach
    • 1
  • R. Margreiter
    • 2
  • A. Königsrainer
    • 2
  • C. Bösmüller
    • 2
  • O. Janko
    • 1
  • P. Brücke
    • 3
  • C. Gross
    • 3
  • J Zazgornik
    • 1
  1. 1. Second Department of Medicine, General Hospital, Linz, AustriaAT
  2. 2. Department of Transplant Surgery, University Hospital, Innsbruck, AustriaAT
  3. 3. First Department of Surgery, General Hospital Linz, AustriaAT

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