Short Communication

Diabetologia

, Volume 56, Issue 10, pp 2176-2180

Family history of diabetes is associated with higher risk for prediabetes: a multicentre analysis from the German Center for Diabetes Research

  • Robert WagnerAffiliated withDepartment of Internal Medicine, Division of Endocrinology, Diabetology, Nephrology, Vascular Disease and Clinical Chemistry, Eberhard Karls UniversityGerman Center for Diabetes Research (DZD)
  • , Barbara ThorandAffiliated withGerman Center for Diabetes Research (DZD)Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Institute of Epidemiology II
  • , Martin A. OsterhoffAffiliated withGerman Center for Diabetes Research (DZD)Department of Clinical Nutrition, German Institute of Human NutritionDepartment of Endocrinology, Diabetes and Nutrition, Charité-University-Medicine Berlin
  • , Gabriele MüllerAffiliated withGerman Center for Diabetes Research (DZD)Institute for Medical Informatics and Biometrics, Technical University Dresden, Medical Faculty Carl Gustav Carus
  • , Anja BöhmAffiliated withDepartment of Internal Medicine, Division of Endocrinology, Diabetology, Nephrology, Vascular Disease and Clinical Chemistry, Eberhard Karls UniversityGerman Center for Diabetes Research (DZD)
  • , Christa MeisingerAffiliated withGerman Center for Diabetes Research (DZD)Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Institute of Epidemiology II
  • , Bernd KowallAffiliated withGerman Center for Diabetes Research (DZD)Institute of Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University
  • , Wolfgang RathmannAffiliated withGerman Center for Diabetes Research (DZD)Institute of Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University
  • , Florian KronenbergAffiliated withDivision of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University
    • , Harald StaigerAffiliated withDepartment of Internal Medicine, Division of Endocrinology, Diabetology, Nephrology, Vascular Disease and Clinical Chemistry, Eberhard Karls UniversityGerman Center for Diabetes Research (DZD)Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tübingen
    • , Norbert StefanAffiliated withDepartment of Internal Medicine, Division of Endocrinology, Diabetology, Nephrology, Vascular Disease and Clinical Chemistry, Eberhard Karls UniversityGerman Center for Diabetes Research (DZD)Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tübingen
    • , Michael RodenAffiliated withDepartment of Internal Medicine, Division of Endocrinology, Diabetology, Nephrology, Vascular Disease and Clinical Chemistry, Eberhard Karls UniversityGerman Center for Diabetes Research (DZD)Institute of Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University
    • , Peter E. SchwarzAffiliated withDepartment of Internal Medicine, Division of Endocrinology, Diabetology, Nephrology, Vascular Disease and Clinical Chemistry, Eberhard Karls UniversityGerman Center for Diabetes Research (DZD)Department for Prevention & Care of Diabetes, Technical University Dresden, Medical Faculty Carl Gustav Carus
    • , Andreas F. PfeifferAffiliated withGerman Center for Diabetes Research (DZD)Department of Clinical Nutrition, German Institute of Human NutritionDepartment of Endocrinology, Diabetes and Nutrition, Charité-University-Medicine Berlin
    • , Hans-Ulrich HäringAffiliated withDepartment of Internal Medicine, Division of Endocrinology, Diabetology, Nephrology, Vascular Disease and Clinical Chemistry, Eberhard Karls UniversityGerman Center for Diabetes Research (DZD)Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tübingen
    • , Andreas FritscheAffiliated withDepartment of Internal Medicine, Division of Endocrinology, Diabetology, Nephrology, Vascular Disease and Clinical Chemistry, Eberhard Karls UniversityGerman Center for Diabetes Research (DZD)Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tübingen Email author 

Abstract

Aims/hypothesis

Prediabetes is a collective term for different subphenotypes (impaired glucose tolerance [IGT] and/or impaired fasting glucose [IFG]) with different pathophysiologies. A positive family history for type 2 diabetes (FHD) is associated with increased risk for type 2 diabetes. We assumed that it would also associate with prediabetes, but wondered whether all subphenotypes are related to a positive family history.

Methods

In a study population of 8,106 non-diabetic individuals of European origin collected from four study centres (normal glucose tolerance, NGT n = 5,482, IFG and/or IGT n = 2,624), we analysed whether having at least one first degree relative with diabetes is associated with prediabetes. The analyses were performed using the same models in each population separately. Afterwards, a meta-analysis was performed.

Results

FHD was significantly associated with the risk for prediabetes (IFG and/or IGT, OR 1.40; 95% CI 1.27, 1.54). This association remained significant in multivariable logistic regression models including sex, age and BMI (OR 1.26; 95% CI 1.14, 1.40). When different prediabetic outcomes were considered separately, the association was found for isolated IFG (OR 1.37; 95% CI 1.20, 1.57), isolated IGT (OR 1.25; 95% CI 1.07, 1.46) as well as for the combination IFG+IGT (OR 1.64; 95% CI 1.40, 1.93). After stratification on BMI, association between FHD and prediabetes was seen only in non-obese individuals (BMI < 30 kg/m2).

Conclusions/interpretation

We found that FHD is an important risk factor for prediabetes, especially for combined IGT and IFG. Its relevance seems to be more evident in the non-obese.

Keywords

DZD Family history German Center for Diabetes Research IFG IGT Meta-analysis Prediabetes