Glycaemic control is improved by 7 days of aerobic exercise training in patients with type 2 diabetes
Cardiovascular events and death are better predicted by postprandial glucose (PPG) than by fasting blood glucose or HbA1c. While chronic exercise reduces HbA1c in patients with type 2 diabetes, short-term exercise improves measures of insulin sensitivity but does not consistently alter responses to the OGTT. The purpose of this study was to determine whether short-term exercise training improves PPG and glycaemic control in free-living patients with type 2 diabetes, independently of the changes in fitness, adiposity and energy balance often associated with chronic exercise training.
Using continuous glucose monitors, PPG was quantified in previously sedentary patients with type 2 diabetes not using exogenous insulin (n = 13, age 53 ± 2 years, HbA1c 6.6 ± 0.2% (49.1 ± 1.9 mmol/mol)) during 3 days of habitual activity and during the final 3 days of a 7 day aerobic exercise training programme (7D-EX) which does not elicit measurable changes in cardiorespiratory fitness or body composition. Diet was standardised across monitoring periods, with modifications during 7D-EX to offset increases in energy expenditure. OGTTs were performed on the morning following each monitoring period.
7D-EX attenuated PPG (p < 0.05) as well as the frequency, magnitude and duration of glycaemic excursions (p < 0.05). Conversely, average 24 h blood glucose did not change, nor did glucose, insulin or C-peptide responses to the OGTT.
7D-EX attenuated glycaemic variability and PPG in free-living patients with type 2 diabetes but did not significantly alter responses to the laboratory-based OGTT. These effects appeared to be independent of changes in fitness, body composition or energy balance.
ClinicalTrials.gov numbers: NCT00954109 and NCT00972452.
Funding: This project was funded by the University of Missouri Institute for Clinical and Translational Sciences (CRM), NIH grant T32 AR-048523 (CRM), Diabetes Action Research and Education Foundation (JPT). Medtronic supplied CGMS sensors at a discounted rate.
- Glycaemic control is improved by 7 days of aerobic exercise training in patients with type 2 diabetes
Volume 55, Issue 5 , pp 1417-1423
- Cover Date
- Print ISSN
- Online ISSN
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- Glycaemic control
- Physical activity
- Postprandial glycaemia
- Type 2 diabetes mellitus
- Industry Sectors
- Author Affiliations
- 1. Department of Nutrition and Exercise Physiology, 10A McKee, University of Missouri, Columbia, MO, 65211, USA
- 2. Department of Medicine, Division of Gastroenterology and Hepatology, University of Missouri, Columbia, MO, USA