Childhood cognitive ability: relationship to gestational diabetes mellitus in India
Our aim was to test the hypothesis that gestational diabetes mellitus (GDM) in mothers is associated with poorer cognitive ability in their offspring in India.
During 1997 to 1998 maternal GDM status was assessed by OGTT at 30 ± 2 weeks of gestation. Between 2007 and 2008, at a mean age of 9.7 years, 515 children (32 offspring of GDM mothers [ODM]; 483 offspring of non-GDM mothers [controls]) from the Mysore Parthenon birth cohort underwent cognitive function assessment using tests from the Kaufman Assessment Battery for Children—Second Edition and additional tests measuring learning, long-term storage/retrieval, short-term memory, reasoning, attention and concentration, and visuo-spatial and verbal abilities.
Compared with controls, ODM scored higher in tests for learning, long-term retrieval/storage (p = 0.008), reasoning (p = 0.02), verbal ability (p = 0.01), and attention and concentration (p = 0.003). In multiple regression, adjusted for the child’s age, sex, gestation, neonatal weight and head circumference, maternal age, parity and BMI, and the parent’s socioeconomic status, education and rural/urban residence, this difference remained significant only for learning, long-term retrieval/storage (β = 0.4 SD (95% CI 0.01–0.75); p = 0.04) and verbal ability (β = 0.5 SD (95% CI 0.09–0.83); p = 0.02), and not with other test scores.
In this population of healthy Indian children, there was no evidence of lower cognitive ability in ODM. In fact some cognitive scores were higher in ODM.
- Seshiah V, Balaji V, Balaji MS, Paneerselvam A, Kapur A (2009) Pregnancy and diabetes scenario around the world. India. Int J Gynaecol Obstet 104:S35–S38 CrossRef
- Dionne G, Boivin M, Séguin JR, Pérusse D, Tremblay RE (2008) Gestational diabetes hinders language development in offspring. Pediatrics 122:e1073–e1079 CrossRef
- Ornoy A (2005) Growth and neurodevelopmental outcome of children born to mothers with pregestational and gestational diabetes. Pediatr Endocrinol Rev 3:104–113
- Hill JC, Krishnaveni GV, Annamma I, Leary SD, Fall CH (2005) Glucose tolerance in pregnancy in South India: relationships to neonatal anthropometry. Acta Obstet Gynecol Scand 84:159–165
- Carpenter MW, Coustan DR (1982) Criteria for screening for gestational diabetes. Am J Obstet Gynecol 159:768–773
- Kaufman AS, Kaufman LN (2004) Kaufman assessment battery for children. Manual, 2nd edn. AGS Publishing, Circle Pines
- Kohs SC (1923) Intelligence measurement: a psychological and statistical study based upon the block-design test. Macmillan, New York CrossRef
- Wechsler D (1991) Manual for the Wechsler Intelligence scale for children, 3rd edn. Psychological Corporation, San Antonio
- Veena SR, Krishnaveni GV, Wills AK et al (2010) Association of birthweight and head circumference at birth to cognitive performance in 9–10 year old children in South India: prospective birth cohort study. Pediatr Res 67:424–429 CrossRef
- International Institute for Population Sciences (IIPS) and Operations Research Centre (ORC) Macro (2001) National Family Health Survey (NFHS-2), India 1998–1999. IIPS, Maharashtra
- Ortega-Senovilla H, Alvino G, Taricco E, Cetin I, Herrera E (2009) Gestational diabetes mellitus upsets the proportion of fatty acids in umbilical arterial but not venous plasma. Diabetes Care 32:120–122 CrossRef
- Childhood cognitive ability: relationship to gestational diabetes mellitus in India
Volume 53, Issue 10 , pp 2134-2138
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- Cognitive function
- Gestational diabetes mellitus
- Industry Sectors
- Author Affiliations
- 1. Epidemiology Research Unit, Holdsworth Memorial Hospital, Mandi Mohalla, P.O. Box 38, Mysore, 570021, India
- 2. St John’s Research Institute, St John’s National Academy of Health Sciences, Bangalore, India
- 3. MRC Epidemiology Resource Centre, Southampton General Hospital, Southampton, UK