Diastolic dysfunction in diabetes and the metabolic syndrome: promising potential for diagnosis and prognosis
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- von Bibra, H. & St John Sutton, M. Diabetologia (2010) 53: 1033. doi:10.1007/s00125-010-1682-3
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Cardiac disease in diabetes mellitus and in the metabolic syndrome consists of both vascular and myocardial abnormalities. The latter are characterised predominantly by diastolic dysfunction, which has been difficult to evaluate in spite of its prevalence. While traditional Doppler echocardiographic parameters enable only semiquantitative assessment of diastolic function and cannot reliably distinguish perturbations in loading conditions from altered diastolic functions, new technologies enable detailed quantification of global and regional diastolic function. The most readily available technique for the quantification of subclinical diastolic dysfunction is tissue Doppler imaging, which has been integrated into routine contemporary clinical practice, whereas cine magnetic resonance imaging (CMR) remains a promising complementary research tool for investigating the molecular mechanisms of the disease. Diastolic function is reported to vary linearly with age in normal persons, decreasing by 0.16 cm/s each year. Diastolic function in diabetes and the metabolic syndrome is determined by cardiovascular risk factors that alter myocardial stiffness and myocardial energy availability/bioenergetics. The latter is corroborated by the improvement in diastolic function with improvement in metabolic control of diabetes by specific medical therapy or lifestyle modification. Accordingly, diastolic dysfunction reflects the structural and metabolic milieu in the myocardium, and may allow targeted therapeutic interventions to modulate cardiac metabolism to prevent heart failure in insulin resistance and diabetes.
KeywordsCardiovascular diseaseDiastolic dysfunctionMetabolic syndromeReviewTissue Doppler imagingType 2 diabetes
Brain natriuretic peptide
Coronary artery disease
Cine magnetic resonance imaging
Early diastolic myocardial velocity, derived from tissue Doppler imaging
Ratio of early diastolic velocities of mitral inflow (Doppler-derived) and myocardial movement (tissue Doppler imaging-derived) taken as left ventricular filling pressure
Systolic myocardial velocity, derived from tissue Doppler imaging
The metabolic syndrome and type 2 diabetes are associated with myocardial dysfunction
The metabolic syndrome is a cluster of risk factors of metabolic origin and has a growing prevalence worldwide [1, 2]. The prototypical patient has non-specific symptoms, obesity and a sedentary lifestyle, and usually receives therapy for metabolic syndrome only after systemic hypertension and/or hyperlipidaemia is diagnosed. However, patients with the metabolic syndrome are at risk of multisystem disease and, accordingly, need early diagnosis and appropriate therapy before the full syndrome and its deleterious sequelae become established. Abdominal adiposity is commonly associated with insulin resistance and the development of a number of cardiovascular risk factors, prominent among which is diabetes mellitus [3, 4]. The most serious complication is coronary artery disease (CAD), which often occurs before overt diabetes mellitus is apparent  and when there is only subtle myocardial dysfunction that is manifest initially in diastole [6, 7]. Because of accumulating evidence for predominantly diastolic dysfunction in diabetic patients without ischaemic, valvular and hypertensive disease, a specific diabetic cardiomyopathy has been proposed . More recently, increased prevalence of diastolic dysfunction has also been shown in the metabolic syndrome .
Early subclinical diastolic dysfunction has only recently been recognised and its predictive value for diastolic heart failure appreciated [10–12], having previously been regarded as benign . Diastolic dysfunction is the most prominent characteristic of diabetic cardiomyopathy [7, 14, 15] and heart failure is the most common cause of death (66%) in patients with type 2 diabetes after their first myocardial infarction . The traditional echocardiographic and Doppler techniques have proved inconclusive for the diagnosis of diastolic dysfunction in diabetic cardiomyopathy and in the metabolic syndrome because there is no consensus regarding definitive diagnostic criteria. Furthermore, evidence-based medicine lacks specific therapy for diastolic dysfunction in general and for diabetic cardiomyopathy in particular, as the commonly recommended treatment options for systolic heart failure have not proved effective [13, 17].
Hence, this review seeks to present an interdisciplinary approach to diastolic dysfunction in diabetes and the metabolic syndrome, focusing on the associated problems, pathophysiology, diagnostic modalities, therapeutic implications and clinical applications.
Prevalence, relevance and prognosis of diastolic dysfunction
There is indisputable evidence for the high prevalence of predominantly diastolic myocardial dysfunction in individuals aged >65 years. This prevalence is 16% in the general population and 35% in individuals with the metabolic syndrome [9, 18]. However, it is 50% in individuals with prediabetes and overt type 2 diabetes, 60% in patients with CAD and 70% in patients with both CAD and diabetes [19–22]. Diastolic myocardial dysfunction with a normal left ventricular ejection fraction is clinically important because it accounts for approximately 50% of all hospital admissions for acute heart failure . For the individual patient, diastolic dysfunction and diastolic heart failure mean impaired quality of life induced by the deterioration in exercise capacity that limits activities of daily living . Patients with the metabolic syndrome and those with diabetes often present with exertional dyspnoea and reduced exercise tolerance, which are due directly to diastolic myocardial dysfunction [9, 22, 24, 25].
Abnormalities of myocardial relaxation, i.e. grade 1 diastolic dysfunction, confer a twofold increase in all-cause and cardiac mortality [10, 11]. This observation has increased awareness of diastolic heart failure with a normal ejection fraction [12, 13]. However, despite the impressive impact of isolated diastolic dysfunction upon mortality, there remains a lack of evidence-based treatment regimes for diastolic dysfunction.
Problems with clinical assessment
Diastolic dysfunction associated with the metabolic syndrome or diabetes is not always detected early. The delay in diagnosis is due partly to patient-related factors and partly to medical oversight. Patients are often ashamed of being overweight, have difficulty losing weight, and become resigned to their physical limitations in daily life and reticent about discussing this problem with their medical practitioner. Furthermore, most diabetologists do not routinely assess levels of physical activity or signs and symptoms of diastolic dysfunction, such as progressive exertional dyspnoea or exercise intolerance. Nor are the 6-min walk test , peak myocardial oxygen consumption or brain natriuretic peptide (BNP) obtained routinely, whereas an electrocardiogram and chest X-ray are obtained but are only occasionally helpful for detecting left ventricular hypertrophy or dilatation. Therefore, more sensitive imaging techniques are required for the early detection of myocardial dysfunction. While there is no consensus for the definition of diastolic dysfunction, there have been recent recommendations by the European Society of Cardiology for the diagnosis of diastolic heart failure . These comprise three obligatory conditions: (1) clinical signs and symptoms of congestive heart failure; (2) normal or only mildly abnormal left ventricular systolic function; and (3) evidence of diastolic dysfunction as shown by abnormal left ventricular relaxation, filling, diastolic distensibility or stiffness in addition to elevated levels of BNP. An E/E′ ratio  (ratio of early diastolic velocities of mitral inflow derived by Doppler imaging and of myocardial movement derived by tissue Doppler imaging) >15 is considered diagnostic of diastolic dysfunction and an E/E′ ratio <8 as diagnostic of the absence of diastolic heart failure. The use of Doppler-derived mitral inflow measures of left ventricular diastolic function is no longer recommended as a first-line diagnostic approach. An increased left atrial size (>49 ml/m2) and an increased left ventricular mass (>122 g/m2 in women and >149 g/m2 in men) are considered sufficient evidence of diastolic dysfunction when the E/E′ ratio is inconclusive.
Pathophysiology of diastolic dysfunction
Diastole is traditionally divided into four phases: (1) isovolumic relaxation; (2) early diastolic filling, i.e. rapid filling; (3) diastasis; and (4) late diastolic filling, i.e. atrial contraction. Two aspects of diastolic function—relaxation and stiffness—are often considered together, but they describe different properties of the myocardium. Relaxation is a dynamic and energy-consuming myocardial process that begins at the end of contraction and continues throughout isovolumic relaxation and early diastolic filling. Impaired relaxation is either delayed or incomplete and may be due to regional dyssynchrony or to a reduction in energy supply, as in myocardial hypertrophy or ischaemia. Diastolic stiffness is measured at the end of diastole after filling has terminated and is determined by the curvilinear pressure–volume relationship. The slope of the tangent (dP/dv) of this relationship defines the chamber stiffness at any given filling pressure. Changes in stiffness may occur as a result of changes in the composition and material properties of the myocardium, such as interstitial fibrosis and left ventricular hypertrophy or both. In the metabolic syndrome and diabetes mellitus, diastolic dysfunction results from abnormal myocardial active relaxation and an increase in passive stiffness due to metabolic derangements and structural remodelling.
Factors involved in the development of diabetic myocardial dysfunction
Early diastolic function depends on both myocardial stiffness and energy availability
For decades, the pathophysiological mechanisms of impaired left ventricular filling have been considered to be mainly a result of increased myocardial stiffness due to structural changes in the myocardium. Myocardial stiffness affects mainly late diastolic function but may also affect relaxation properties. A recent study based on left ventricular endomyocardial biopsy samples showed that systolic heart failure in diabetic patients was due to increased myocardial stiffness that was mainly associated with AGE deposition and fibrosis. However, the main contributors to diastolic heart failure were high cardiomyocyte resting tension and hypertrophy . Of interest, myocellular hypertrophy in diabetes was unrelated to pressure overload but associated with elevated fasting insulin levels, implicating insulin resistance as a factor contributing to myocyte hypertrophy.
In addition to stiffness, there is also a reversible dynamic component based on the fact that early diastolic relaxation and filling are energy-consuming, active processes. Two well accepted examples of this dynamic component are the immediate and reversible nature of diastolic dysfunction during stress testing  and during coronary arterial balloon inflation, which may be regarded as an iatrogenic model of regional and intermittent impairment of myocardial energy supply in man . This model, with an exact onset and offset of perfusion blockade, has confirmed the increased susceptibility of myocardial diastolic function to energy derangements by the occurrence of diastolic dysfunction, not only before but also extending far beyond systolic dysfunction. Limitations in energy supply may arise not only from deficiencies in circulatory transport and perfusion but also from the intracellular processes involved in biochemical energy production and substrate utilisation [15, 31, 38, 39].
Metabolic abnormalities leading to reduced energy availability
Abnormal insulin signalling and increased production of reactive oxygen species [32, 33] have recently been demonstrated in individuals with uncomplicated type 2 diabetes . Many of the possible mechanisms of action of reactive oxygen species involve the regulation of energy availability. Indirect effects may involve downregulated perfusion by induction of endothelial dysfunction [35, 48]. Direct effects on cardiomyocytes result in impaired mitochondrial energy production by altered substrate supply and utilisation [38, 49] and mitochondrial uncoupling, which reduces cardiac efficiency  and alters insulin signalling. The latter plays a key role in insulin resistance , reduced bioavailability of nitric oxide , altered handling of calcium  and mitochondrial damage and dysfunction, culminating in abnormal cardiac remodelling and ventricular dysfunction . Acknowledging diastolic dysfunction as an indicator of reduced myocardial energy availability would provide a better understanding of why augmentation may be observed with short-term improvement of glycaemic control in type 2 diabetes  and with acutely increased myocardial perfusion by C-peptide administration in young and athletic individuals with type 1 diabetes . There is an increasing number of reports showing that the extent of hyperglycaemia correlates with diabetic myocardial dysfunction [30, 55, 56], that good metabolic control reduces the risk of heart failure [57, 58] and that the improvement in diastolic function correlates with the extent of improved glucose control [53, 55, 59]. The optimal glucose-lowering regimen for the protection of patients with diabetes against diastolic heart failure needs to be determined in further studies.
Cardiovascular risk factors determine diastolic function
Rapid filling of the left ventricle has been shown to be a sensitive indicator of all types of myocardial damage, being susceptible not only to age and ischaemia but also to virtually all cardiovascular risk factors, including the metabolic syndrome [9, 19, 45, 60–62]. Concordant with these findings is the reversibility of impaired diastolic function, as demonstrated by effective treatment of any of these risk factors, including a sedentary lifestyle and obesity [53, 60, 63–66]. Notably, the reversibility of myocardial abnormalities associated with the metabolic syndrome and diabetes is welcome news for patients and their physicians and is in accord with the recent message from the UK Prospective Diabetes follow-up study, that the most effective treatment is started early in the course of the disease .
Age dependence of diastolic function differentiates normal function from dysfunction
Myocardial velocity measurements by tissue Doppler imaging clearly demonstrate the predominant influence of ageing on diastolic function [68, 69], confirming previous reports using different imaging techniques. There is a steep and linear decline of normal early diastolic velocity with ageing in normal people, from 16 cm/s at the age of 20 years to 6 cm/s at 80 years. This decline equals a decrease of 0.16 cm/s (i.e. 1% of the original value) every year. Accordingly, cut-off values for normality vs dysfunction should be defined in a linear regression equation as a function of age . Using pulsed tissue Doppler imaging, the cut-off level for normal age-related velocity is calculated as −0.15 × age (years) + 18 (cm/s). This approach allows individual patients to be assigned to normality or dysfunction/risk and avoids the inconsistencies arising from normal values defined for different age groups. There are no sex-related differences in the association of diastolic function and age. E′ is also useful in the detection of impaired left ventricular relaxation and estimation of filling pressure (E/E′) in patients with atrial fibrillation .
Echocardiography and Doppler imaging for traditional left ventricular function assessment
Similarly, the traditional measurements of diastolic function, the Doppler-derived mitral valve inflow velocity pattern and its derivatives, have proved difficult to interpret because of the pseudonormal pattern, that defines grade 2 dysfunction, but may be mistaken for the normal pattern  (Fig. 3c), unless differentiation by the Valsalva manoeuvre or by assessing pulmonary vein flow is performed. While the clinical course of diastolic dysfunction is characterised by decreasing effectiveness of myocardial relaxation and extension associated with increasing left atrial pressure and size, the respective developments of pressure and filling cannot be mirrored by the traditional Doppler parameters. An even more important limitation, however, is the non-quantitative pattern recognition used for assessing diastolic function and the changes in the course of disease and during preventive therapy.
Pulsed tissue Doppler imaging
Colour Doppler tissue imaging
Myocardial velocity measurements can also be obtained using two-dimensional high frame rate (120 frames/min) colour tissue Doppler imaging and off-line analysis to reconstruct time–velocity curves. It is important to note that the recording of these velocities is based on autocorrelation and not on fast Fourier analysis as in pulsed tissue Doppler imaging. Accordingly, velocities from colour Doppler imaging are intrinsically lower by 1.8 ± 1.6 cm/s compared with velocities derived by pulsed tissue Doppler imaging , so that these two techniques should not be interchanged in sequential studies.
Both tissue Doppler techniques have been used successfully to quantify myocardial diastolic and systolic function at rest [9, 19, 28, 30, 60, 75] and during stress [19, 45, 79] and have consistently demonstrated impaired diastolic function in patients with the metabolic syndrome and/or diabetes mellitus type 1 and type 2. Thus, tissue Doppler velocity measurements appear to compensate for the deficiencies of the traditional less precise measures of diastolic function in these patients, and accordingly provide the basis for large-scale therapeutic studies in subclinical and low-grade myocardial disease.
Doppler-based strain and strain rate imaging
The theoretical advantage of two-dimensional colour Doppler imaging is that routine images may be acquired for subsequent off-line analysis of velocity, strain (change in myocardial length/resting myocardial length) and strain rate (rate of change of strain [dS/dt]). Strain and strain rate enable assessment of regional and global myocardial mechanical function and appear particularly suitable in CAD and its complications  but they have not been integrated into routine clinical practice . However, pulsed tissue Doppler imaging has demonstrated greater sensitivity for the detection of diastolic dysfunction than strain and strain rate [81, 82], which is important since diastolic dysfunction commonly precedes systolic dysfunction, especially in CAD, the metabolic syndrome and diabetes mellitus [6, 19, 21, 24, 38, 61, 62].
Speckle tracking-based strain and strain rate imaging
The most recent ultrasound development for function assessment, strain and strain rate imaging based on speckle tracking is currently being evaluated . This technology uses ultrasound reflectors within the myocardium to characterise regional myocardium by tracking these reflectors during systolic shortening and relaxation in two and, potentially, three dimensions. Moreover, this technology is not constrained spatially by the angle dependency of Doppler imaging. In addition, speckle tracking allows the evaluation of left ventricular twist and torsion patterns during left ventricular contraction, ejection, relaxation and filling. These patterns are different in systolic heart failure compared with diastolic heart failure and await further clarification . The prognostic value of this technology for the routine assessment of subclinical disease in the metabolic syndrome is not yet known. A limitation of speckle tracking in the assessment of diastolic function is the relatively low frame rate compared with the higher frame rate of pulsed tissue Doppler imaging. Speckle tracking is based on two-dimensional echocardiographic image quality, which may be problematic in overweight patients with the metabolic syndrome and type 2 diabetes. In contrast, pulsed tissue Doppler velocity signals are relatively independent of human tissue attenuation, resulting in velocity recordings that can be analysed even in obese individuals who are difficult to image by two-dimensional echocardiography [45, 85].
Cine magnetic resonance imaging
Cine magnetic resonance imaging (CMR) is the gold standard for the quantitative assessment of left ventricular mass and volumes, from which systolic function may be determined . This non-ionising imaging method has excellent three-dimensional spatial resolution. As a consequence of the complex spatial data acquisition in either the gradient echo or the phase-contrast imaging technique, there are some limitations in temporal resolution. Most CMR technologies have a time resolution ≥ 30 ms; that for fast breath-hold gradient echo imaging and CMR fluoroscopy resolution is 15–25 ms and that for CMR tissue tagging is ≥20 ms . Gradient echo imaging uses repetitive radiofrequency pulses gated to the electrocardiogram so that cine images may be generated during a single breath-hold. Phase-contrast CMR allows velocity encoding of moving structures and blood using the spin phase shift as the basic principle for velocity measurement. Commercially available quantitative CMR software uses spatial modulation of magnetisation (SPAMM) tagging to characterise regional wall motion inhomogeneities . This technique may offer greater accuracy for the detection of regional systolic dysfunction analogous to speckle tracking-derived strain and strain rate. However, it shares with speckle tracking the disadvantages of lower frame rates (50 frames/s) compared with pulsed tissue Doppler imaging, which is not ideal for the assessment of diastolic function. At present, the use of CMR for the assessment of diastolic function may be considered a research tool because of its high cost, limited availability and the need for time-consuming offline data reduction and analysis associated with non-ideal temporal resolution.
The use of contrast agents such as gadolinium to mark scarred myocardium, fibrosis or inflammation by delayed contrast enhancement has been integrated into clinical routine. Magnetic resonance spectroscopy has the potential to recognise changes in myocardial bioenergetics and metabolism, such as increased lipid supply by 1H-magnetic resonance spectroscopy and altered high-energy phosphate metabolism assessed by 31P-magnetic resonance spectroscopy for measuring the phosphocreatine–ATP ratio (PCr/ATP). These technologies may open new windows on the links between altered metabolism and function in the diabetic heart. First reports demonstrate reduced diastolic function in well controlled patients with uncomplicated type 2 and type 1 diabetes compared with age-matched controls associated with impaired myocardial energy metabolism [38, 49]. Reduced diastolic function has also been observed in type 2 diabetic patients with myocardial steatosis  and in middle-aged compared with younger healthy individuals, but is improved in middle-aged individuals on long-lasting aerobic training, paralleled by the PCr/ATP ratio .
Summary of imaging techniques
Apart from histological and molecular changes in the diabetic myocardium, which are not the focus of this review, there is growing evidence that diastolic and systolic myocardial dysfunction can be and should be routinely quantified by tissue Doppler imaging. Low cost, wide availability, superior temporal resolution and on-line velocity analysis make pulsed tissue Doppler the imaging modality of choice to investigate the presence of left ventricular dysfunction in diabetes or the metabolic syndrome. A specific research advantage of CMR techniques is the ability to assess changes in tissue composition as well as alterations in myocardial metabolism by spectroscopy.
Preventive medicine and diastolic function
Evidence-based medicine has demonstrated improvement of cardiovascular mortality in individuals with type 2 diabetes mellitus by glucose-lowering drugs and/or other medical therapy, but diastolic function has not been measured. Neither are there any evidence-based studies of patients with diabetes and diastolic heart failure.
Therapeutic effect on diastolic function in patients with diabetes mellitus
First author [reference no.]
No. of individuals (age [years])
Patients’ diabetes and cardiac specifications
Study duration (months)
Metabolic and clinical findings
Effect on diastolic function (imaging technique)
von Bibra 
T2D, no HF
Increase in insulin vs metformin
Fasting glucose reduced by 3.7 mmol/l in both groups
E′ improved (from 7.5 to 8.6 cm/s) in insulin group (pTDI)
T1D, no CAD, BMI <25 kg/m2, normotensive
Increase in insulin
HbA1c reduced to 8.1%, fasting glucose by 1.0 mmol/l
Peak LV diameter lengthening rate improved (from 4.4 to 5.2 s−1) (digitised M-mode echo)
von Bibra 
T2D, no HF
Increase in insulin
0.7 and 12
Fasting glucose reduced by 1.5 mmol/l
E′ improved (from 7.6 to 8.3 cm/s) (pTDI)
6.0 and 5.9
T2D, no insulin, no CAD or HF, ultrasonographic signs of diastolic dysfunction
Increase in insulin vs OAD
HbA1c reduced to 5.2%, fasting glucose by 1.0 mmol/l in both groups
E′ unchanged in both groups (10.3 cm/s) (pTDI)
von Bibra 
T2D, no HF, well controlled on CT vs ICT for 24 months, HbA1c and fasting glucose comparable
Pure carbohydrate (48 g) test meal
Δ glucose 3.3 with CT vs 1.0 mmol/l with ICT
E′ worse in CT (6.8 cm/s) vs ICT (7.7 cm/s) (pTDI)
Sedentary T2D on diet or OAD, well controlled, no CAD
Aerobic exercise programme vs no exercise
M⩒O2 increased (from 28.6 to 32.7 ml kg−1 min−1) with exercise
Improvement in diastolic dysfunction with exercise (echo-Doppler)
T2D, no CAD, no HF
Moderate/vigorous (gym) exercise vs no gym
Improved 6-min walk test, heart rate in both groups but BMI, HDL, blood pressure, ⩒O2 with exercise
Improvement of E′ by 0.5 cm/s, systolic velocity by 0.7 cm/s in both groups (colour tissue Doppler imaging)
T2D, on insulin, C-peptide >0.8 ng/l, BMI 36 kg/m2, no CAD
Very-low-energy diet (450 kcal [1882 kJ]/day) and insulin discontinued
BMI reduced to 28 kg/m2, HbA1c to 6.7%, fasting glucose from 11.4 to 6.7 mmol/l, TG from 2.1 to 1.1 mmol/l
Decrease in myocardial TG content (from 0.88% to 0.64%) and left ventricular mass (from 118 to 99 g), increase in E/A (CMR)
von Bibra 
T2D, metformin-treated, no CAD or HF
Rosiglitazone (8 mg) vs glimepiride (3 mg)
Fasting glucose reduced by 1.0 and postmeal glucose by 2.0 mmol/l by rosiglitazone
E′ improved (from 7.9 to 8.9 cm/s) by rosiglitazone with a significant association with malondialdehyde reduction (pTDI)
van der Meer 
Uncomplicated T2D, no use of insulin, no CAD
Pioglitazone (30 mg) vs metformin (2 g)
Fasting glucose reduced by 0.8 mmol/l by pioglitazone
Filling rate improved by pioglitazone vs metformin (CMR)
T2D on ICT, no CAD, no or mild hypertension
Ramipril (10 mg) vs no ramipril
Glycaemic control and blood pressure unchanged in both groups
E′ improved (from 7.8 to 8.6 cm/s) by ramipril (pTDI)
CAD, no HF or MI; diabetes in 30% of individuals
Statin vs no statin
Cardiac death or HF 2.3% in statin vs 15.4% in no statin group
LV filling pressure (E/E′) and no statin are multivariate predictors of death and HF (pTDI)
Glycaemic control is not the only contributor to diastolic dysfunction, as suggested by two detailed studies of diabetic metabolism during treatment with glitazones. An extensive CMR study comparing pioglitazone with metformin  showed functional improvement in the glitazone group only but metabolic improvement in both groups, and did not find any correlation between the change in diastolic function and increased myocardial glucose uptake or altered substrate metabolism.
A tissue Doppler imaging crossover study comparing rosiglitazone with glimepiride demonstrated improved fasting and postprandial glucose values and diastolic function for rosiglitazone only. In addition, this study showed a close relationship between the reduction of malondialdehyde (a marker of oxidative stress) and improvement in diastolic function .
With regard to cardiovascular preventive medications, first reports describe improved diastolic function and or prognosis with statin therapy [21, 65]. Similarly, improvements in diastolic function have been observed in hypertensive and diabetic patients treated with ACE inhibitors, calcium antagonists, angiotensin II type 1 (AT1) blockers or beta blockers [60, 100–102].
Clinical application of imaging
Surrogate variable or direct observation of pathological myocardial function
In order to screen individuals with the metabolic syndrome or diabetes mellitus for myocardial dysfunction, most physicians would prefer a reliable and effective blood test as a surrogate variable compared with the more costly diagnosis by echocardiography. There is increasing evidence that BNP is a sensitive marker of congestive heart failure and acute coronary syndromes . However, BNP does not appear to be a sensitive or specific marker for the early detection of preclinical myocardial dysfunction, in particular diastolic dysfunction [104, 105]. The sensitivity of BNP testing was reported recently as only 63% in diabetic patients with subclinical myocardial dysfunction . Furthermore, its potential to monitor therapeutic efficacy appears uncertain, as suggested by the outcome of the Steno-2 Study in 160 patients with type 2 diabetes mellitus and microalbuminuria. In this study, multimodal therapy induced significant improvement in metabolic control and cardiovascular risk factors, but BNP increased significantly . Thus, the use of BNP cannot be considered effective for the assessment of subclinical diastolic dysfunction.
Preventive cardiovascular medicine should ideally use diagnostic measurements that involve direct observation of the pathological changes in the myocardium rather than rely upon identification of epiphenomenal risk factors or surrogate biomarkers. At present, however, it is premature to make recommendations about when, how often and which selection of diabetic patients should be imaged to assess baseline diastolic function. The clinical picture, in particular a reduced exercise capacity limiting normal daily activities, should raise suspicion of undiagnosed diastolic dysfunction and initiate referral to a cardiologist for diagnostic ultrasonography. Similarly, a combination of obesity, insulin resistance, mediocre glycaemic control and further cardiovascular risk factors or CAD should indicate a diagnostic assessment for early preventive action. Because of the current lack of evidence-based therapeutic strategies, preventive action should focus on addressing the underlying pathophysiological mechanisms of the metabolic disease by at least recommending lifestyle changes. Regular physical training/activity and dietary modification lack side effects and have had a success rate better than that of preventive drug therapy, at least in CAD patients .
Highly sensitive variables are needed for individual patient management
Whereas the clinical endpoints that are used in evidence-based preventive medicine are often unsuitable for tailoring individual patient therapy, the quantification of ideal sensitive and routinely available current variables is required in order to demonstrate therapeutic efficacy. Many of the large clinical trials report the significance of small numerical differences between the control group and the active treatment arms, but this has little or no clinical relevance for individual patients. Accordingly, it remains of clinical interest to study highly sensitive variables, which have the potential to become significant in small patient numbers, e.g. in eight to 15 observed cases. These variables may yield meaningful individual differences when compared before and after therapeutic interventions, as has been shown to be true for diastolic myocardial velocity quantified by pulsed tissue Doppler imaging and reported to be suitable for supporting therapeutic decision-making [47, 53, 54, 100].
The cardiovascular disease associated with the metabolic syndrome and with diabetes mellitus comprises vascular and myocardial abnormalities. This myocardial dysfunction is characterised predominantly by diastolic dysfunction consisting of relaxation abnormalities that are prevalent and have prognostic importance. Diastolic dysfunction can be detected and quantified by pulsed tissue Doppler imaging as a clinical routine and assigned to normality vs dysfunction by using the linear inverse relation of individual age to diastolic function. Diastolic dysfunction is a direct measure of structural and dynamic, metabolically induced, pathophysiological processes in the myocardium. Tissue Doppler imaging has the potential to meet the present need for a robust tool that can establish therapeutic efficacy in future preventive studies of insulin resistance, diabetes and cardiovascular disease and, thus, should be used to identify (pre-) diabetic individuals with diastolic dysfunction and to optimise their clinical management.
This work was supported in part by grants to H. von Bibra by the Heidenhain Foundation, the Swedish Technical Research Council, the Swedish Heart Lung Foundation, the Swedish Medical Research Council (project no. 11201), the German Cardiac Society and Baden-Wuertemberg LVA Pension System. M. St John Sutton is funded by the Commonwealth of Pennsylvania.
Duality of interest
The authors declare that there is no duality of interest associated with this manuscript.
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