The effect of bilio-pancreatic diversion on type 2 diabetes in patients with BMI <35 kg/m2
- C. ChielliniAffiliated withDepartment of Internal Medicine, Catholic University
- , F. RubinoAffiliated withWeill Cornell Medical College/New York Presbyterian Hospital
- , M. CastagnetoAffiliated withDepartment of Surgery, Catholic University
- , G. NanniAffiliated withDepartment of Surgery, Catholic University
- , G. MingroneAffiliated withDepartment of Internal Medicine, Catholic University Email author
To aim of the study was to investigate the effect of bilio-pancreatic diversion (BPD) on type 2 diabetes in patients with BMI <35 kg/m2.
OGTTs were performed and anthropometric data were compared between five diabetes patients (BMI 27–33 kg/m2) following BPD and seven diabetes patients after a low-energy diet. Insulin secretion was computed by C-peptide deconvolution. A euglycaemic–hyperinsulinaemic clamp was performed only in the BPD group and the M value measured.
One month after BPD, fasting and 2 h post-OGTT glycaemia decreased from 15.22 ± 3.22 to 6.22 ± 0.51 mmol/l (p = 0.043), while insulin sensitivity increased significantly. No significant changes were observed in the low-energy diet group. Insulin secretion did not differ significantly after either intervention. Diabetes amelioration (change in HbA1c level) was observed up to 18 months after BPD without pharmacological therapy.
BPD can achieve adequate control of type 2 diabetes also in patients with BMI <35 kg/m2. The rapid postoperative remission of diabetes is primarily related to an improvement in insulin sensitivity.
KeywordsBilio-pancreatic diversion BMI <35 kg/m2 Hypocaloric diet Insulin secretion Insulin sensitivity Type 2 diabetes
- The effect of bilio-pancreatic diversion on type 2 diabetes in patients with BMI <35 kg/m2
Volume 52, Issue 6 , pp 1027-1030
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- Bilio-pancreatic diversion
- BMI <35 kg/m2
- Hypocaloric diet
- Insulin secretion
- Insulin sensitivity
- Type 2 diabetes
- Industry Sectors
- Author Affiliations
- 1. Department of Internal Medicine, Catholic University, Largo A. Gemelli, 8, 00168, Rome, Italy
- 2. Weill Cornell Medical College/New York Presbyterian Hospital, New York, USA
- 3. Department of Surgery, Catholic University, Rome, Italy