, Volume 50, Issue 12, pp 2602-2603
Date: 05 Oct 2007

Variation in the FTO gene locus is associated with cerebrocortical insulin resistance in humans

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To the Editor: In a genome-wide association study, the FTO locus has recently been identified as a gene associated with increased risks of obesity and type 2 diabetes mellitus in humans [13]. Dina et al. [4] reported that variation in this gene is strongly associated with childhood and severe adult obesity. In this paper, three single nucleotide polymorphisms are proposed to be functional and were reported to be in high linkage disequilibrium with the variants rs8050136 and rs9939609 reported by Scott et al. [1] and Frayling et al. [2], respectively. The overall weight effect of the risk genotype has been estimated to be approximately 3 kg and was detectable in children from age 7 years upwards [2]. These studies suggest that variants in the FTO gene cause an early onset deterioration of body weight regulation. Based on this, we investigated the relationship between the FTO variant rs8050136 and BMI using data obtained from the Tübingen Family (TÜF) Study [5]. BMI was higher in carrie ...

An erratum to this article can be found at http://dx.doi.org/10.1007/s00125-008-1059-z