Estimating glomerular filtration rate in diabetes: a comparison of cystatin-C- and creatinine-based methods
We compared the predictive performance of a GFR based on serum cystatin C levels with commonly used creatinine-based methods in subjects with diabetes.
Subjects, materials and methods
In a cross-sectional study of 251 consecutive clinic patients, the mean reference (plasma clearance of 99mTc-diethylene-triamine-penta-acetic acid) GFR (iGFR) was 88±2 ml min−1 1.73 m−2. A regression equation describing the relationship between iGFR and 1/cystatin C levels was derived from a test population (n=125) to allow for the estimation of GFR by cystatin C (eGFR-cystatin C). The predictive performance of eGFR-cystatin C, the Modification of Diet in Renal Disease 4 variable formula (MDRD-4) and Cockcroft–Gault (C–G) formulas were then compared in a validation population (n=126).
There was no difference in renal function (ml min−1 1.73 m−2) as measured by iGFR (89.2±3.0), eGFR-cystatin C (86.8±2.5), MDRD-4 (87.0±2.8) or C–G (92.3±3.5). All three estimates of renal function had similar precision and accuracy.
Estimates of GFR based solely on serum cystatin C levels had the same predictive potential when compared with the MDRD-4 and C–G formulas.
- Estimating glomerular filtration rate in diabetes: a comparison of cystatin-C- and creatinine-based methods
Volume 49, Issue 7 , pp 1686-1689
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- Cystatin C
- Diabetic nephropathy
- Glomerular filtration rate
- Renal insufficiency
- Industry Sectors
- Author Affiliations
- 1. Endocrine Centre and the Department of Medicine, Austin Health and University of Melbourne, Heidelberg Repatriation Hospital, Level 2, Centaur Building, Heidelberg West, VIC, 3081, Australia
- 2. Danielle Alberti Memorial Centre for Diabetes Complications, Baker Medical Research Institute, Melbourne, VIC, Australia
- 3. Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, VIC, Australia
- 4. Division of Laboratory Medicine, Austin Health, Heidelberg, VIC, Australia
- 5. Department of Nephrology, Austin Health, Heidelberg, VIC, Australia