Diabetologia

, Volume 49, Issue 6, pp 1456–1456

Impaired beta cell glucose sensitivity and whole-body insulin sensitivity as predictors of hyperglycaemia in non-diabetic subjects

Authors

    • Diabetes Research GroupUniversity of Newcastle upon Tyne
    • School of Clinical Medical Sciences, The Medical School
  • A. Mari
    • CNR Institute of Biomedical Engineering
  • M. K. Jayapaul
    • Diabetes Research GroupUniversity of Newcastle upon Tyne
  • S. M. A. Bennett
    • Diabetes Research GroupUniversity of Newcastle upon Tyne
  • E. Ferrannini
    • University of Pisa School of Medicine
Erratum

DOI: 10.1007/s00125-006-0204-9

Cite this article as:
Walker, M., Mari, A., Jayapaul, M.K. et al. Diabetologia (2006) 49: 1456. doi:10.1007/s00125-006-0204-9
Unfortunately the values given for insulin sensitivity and disposition index (DI) in Tables 2 and 3 of this article were incorrect. The corrected tables are reproduced here. There was also a mistake in the legend for Figure 3 which should have read: ‘Data points and bars are mean ± SE for insulin sensitivity and for beta cell glucose sensitivity’, instead of ‘Data points and bars are mean ± SE for insulin sensitivity and median ± SE for beta cell glucose sensitivity’.
Table 2

Baseline metabolic parameters according to progression to hyperglycaemia

 

Progressors

Non-progressors

p

Fasting ISR (pmol min−1 m−2)

76 (36)

61 (28)

<0.05

Total IS (nmol m−2)

45 (22)

37 (20)

0.09

Beta cell glucose sensitivity (pmol min−1 m−2 mmol/l−1)

75 (48)

110 (98)

0.02

Rate sensitivity (nmol m−2 mmol/l−1)

0.6 (0.7)

0.7 (0.8)

NS

Potentiation (fold)

1.4 (0.7)

1.7 (1.0)

NS

Insulin sensitivity (ml min−1 m−2)

359±55

405±63

0.001

ΔI30/ΔG30 (pmol/mmol)

95 (91)

122 (104)

NS

DI (ml min−1 m−2 pmol mmol−1)

34 (33)

46 (39)

<0.02

Data appear as the mean ± SD or as the median and interquartile range (the difference between the 75th and 25th percentile numbers). ISR Insulin secretion rate; IS insulin secretion; DI disposition index; NS not significant

Table 3

Changes in metabolic data between baseline and 5 years according to progression to hyperglycaemia

 

Progressors

Non-progressors

p

BMI

1.8±2.6

0.8±2.3

0.001

Fasting ISR

18 (38)

3 (37)

0.01

Total IS

3 (24)

1 (22)

NS

Beta-cell glucose sensitivity

−36 (36)

−13 (105)

<0.0001

Rate sensitivity

−0.1 (0.7)

0.01 (0.9)

NS

Potentiation

0.1 (0.9)

−0.1 (1.2)

NS

Insulin sensitivity

−36±57

5±48

<0.0001

ΔI30/ΔG30

−31 (60)

−21 (74)

0.03

DI

−13 (18)

−9 (27)

0.0001

Units for each measurement as described in Tables 1 and 2. Data appear as the mean ± SD or as the median and interquartile range (the difference between the 75th and 25th percentile numbers)

Copyright information

© Springer-Verlag 2006