Diabetologia

, Volume 49, Issue 6, pp 1456–1456

Impaired beta cell glucose sensitivity and whole-body insulin sensitivity as predictors of hyperglycaemia in non-diabetic subjects

  • M. Walker
  • A. Mari
  • M. K. Jayapaul
  • S. M. A. Bennett
  • E. Ferrannini
Erratum

DOI: 10.1007/s00125-006-0204-9

Cite this article as:
Walker, M., Mari, A., Jayapaul, M.K. et al. Diabetologia (2006) 49: 1456. doi:10.1007/s00125-006-0204-9
Unfortunately the values given for insulin sensitivity and disposition index (DI) in Tables 2 and 3 of this article were incorrect. The corrected tables are reproduced here. There was also a mistake in the legend for Figure 3 which should have read: ‘Data points and bars are mean ± SE for insulin sensitivity and for beta cell glucose sensitivity’, instead of ‘Data points and bars are mean ± SE for insulin sensitivity and median ± SE for beta cell glucose sensitivity’.
Table 2

Baseline metabolic parameters according to progression to hyperglycaemia

 

Progressors

Non-progressors

p

Fasting ISR (pmol min−1 m−2)

76 (36)

61 (28)

<0.05

Total IS (nmol m−2)

45 (22)

37 (20)

0.09

Beta cell glucose sensitivity (pmol min−1 m−2 mmol/l−1)

75 (48)

110 (98)

0.02

Rate sensitivity (nmol m−2 mmol/l−1)

0.6 (0.7)

0.7 (0.8)

NS

Potentiation (fold)

1.4 (0.7)

1.7 (1.0)

NS

Insulin sensitivity (ml min−1 m−2)

359±55

405±63

0.001

ΔI30/ΔG30 (pmol/mmol)

95 (91)

122 (104)

NS

DI (ml min−1 m−2 pmol mmol−1)

34 (33)

46 (39)

<0.02

Data appear as the mean ± SD or as the median and interquartile range (the difference between the 75th and 25th percentile numbers). ISR Insulin secretion rate; IS insulin secretion; DI disposition index; NS not significant

Table 3

Changes in metabolic data between baseline and 5 years according to progression to hyperglycaemia

 

Progressors

Non-progressors

p

BMI

1.8±2.6

0.8±2.3

0.001

Fasting ISR

18 (38)

3 (37)

0.01

Total IS

3 (24)

1 (22)

NS

Beta-cell glucose sensitivity

−36 (36)

−13 (105)

<0.0001

Rate sensitivity

−0.1 (0.7)

0.01 (0.9)

NS

Potentiation

0.1 (0.9)

−0.1 (1.2)

NS

Insulin sensitivity

−36±57

5±48

<0.0001

ΔI30/ΔG30

−31 (60)

−21 (74)

0.03

DI

−13 (18)

−9 (27)

0.0001

Units for each measurement as described in Tables 1 and 2. Data appear as the mean ± SD or as the median and interquartile range (the difference between the 75th and 25th percentile numbers)

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • M. Walker
    • 1
    • 4
  • A. Mari
    • 2
  • M. K. Jayapaul
    • 1
  • S. M. A. Bennett
    • 1
  • E. Ferrannini
    • 3
  1. 1.Diabetes Research GroupUniversity of Newcastle upon TyneNewcastle upon TyneUK
  2. 2.CNR Institute of Biomedical EngineeringPadovaItaly
  3. 3.University of Pisa School of MedicinePisaItaly
  4. 4.School of Clinical Medical Sciences, The Medical SchoolNewcastle upon TyneUK