, Volume 49, Issue 5, pp 1112-1114
Date: 11 Mar 2006

Human resistin promotes macrophage lipid accumulation

This is an excerpt from the content

To the Editor:

The gene encoding resistin/FIZZ3 (found in inflammatory zone 3), which is denoted by the gene symbol RETN in humans and Retn in mice, belongs to a new gene family of small cysteine-rich secretory proteins, called ‘resistin-like molecules’, originally discovered in a search for adipocyte-derived molecules linking obesity and insulin-resistant diabetes [1]. In rodents, resistin is derived largely from adipose tissue. Hyperresistinaemia impairs glucose tolerance and induces insulin resistance in mice; mice deficient in resistin (Retn [−/−]) [2], or expressing a dominant negative form of this molecule [3], are protected from obesity-associated insulin resistance.

By contrast, in humans, expression of RETN, which shows significant sequence and tissue divergence from its murine counterpart, is highly localised to bone marrow cells, upregulates during monocyte–macrophage differentiation [4], and triggers inflammatory and proliferative responses in vascular cells [5]. Plasma level