, Volume 45, Issue 10, pp 1468–1474

Peptide therapy for Type I diabetes: the immunological homunculus and the rationale for vaccination

  •  I. Cohen
For Debate

DOI: 10.1007/s00125-002-0937-z

Cite this article as:
Cohen, I. Diabetologia (2002) 45: 1468. doi:10.1007/s00125-002-0937-z


The autoimmune process that produces Type I (insulin-dependent) diabetes mellitus seems to respond favourably to therapeutic vaccination with a peptide of the 60 kDa heat shock protein. This article is a personal review of the observations and the thinking that gave rise to the idea of therapeutic peptide vaccination. The rationale for vaccination therapy is compared to other approaches aimed at specific immunological treatment for autoimmune disease.

Type I diabetes autoimmune disease vaccination HSP60 peptide p277 immune modulation hypothesis driven research immunological homunculus
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© Springer-Verlag 2002

Authors and Affiliations

  •  I. Cohen
    • 1
  1. 1.The Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel