“Bicellar” Lipid Mixtures as used in Biochemical and Biophysical Studies
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- Katsaras, J., Harroun, T.A., Pencer, J. et al. Naturwissenschaften (2005) 92: 355. doi:10.1007/s00114-005-0641-1
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Over the past decade “bicellar” lipid mixtures composed of the long-chain dimyristoyl phosphatidylcholine (DMPC) and the short-chain dihexanoyl PC (DHPC) molecules have emerged as a powerful medium for studying membrane associated, biologically relevant macromolecules and assemblies. Depending on temperature, lipid concentration and composition these lipid mixtures can assume a variety of morphologies, some of them alignable in the presence of a magnetic field. This article will examine the biophysical studies that have elucidated the various morphologies assumed by these lipid mixtures, and their use in the biochemical studies of biomolecules.