Naturwissenschaften

, Volume 92, Issue 8, pp 355–366

“Bicellar” Lipid Mixtures as used in Biochemical and Biophysical Studies

  • John Katsaras
  • Thad A. Harroun
  • Jeremy Pencer
  • Mu-Ping Nieh
Review

DOI: 10.1007/s00114-005-0641-1

Cite this article as:
Katsaras, J., Harroun, T.A., Pencer, J. et al. Naturwissenschaften (2005) 92: 355. doi:10.1007/s00114-005-0641-1

Abstract

Over the past decade “bicellar” lipid mixtures composed of the long-chain dimyristoyl phosphatidylcholine (DMPC) and the short-chain dihexanoyl PC (DHPC) molecules have emerged as a powerful medium for studying membrane associated, biologically relevant macromolecules and assemblies. Depending on temperature, lipid concentration and composition these lipid mixtures can assume a variety of morphologies, some of them alignable in the presence of a magnetic field. This article will examine the biophysical studies that have elucidated the various morphologies assumed by these lipid mixtures, and their use in the biochemical studies of biomolecules.

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • John Katsaras
    • 1
  • Thad A. Harroun
    • 1
    • 2
  • Jeremy Pencer
    • 1
    • 3
  • Mu-Ping Nieh
    • 1
  1. 1.National Research CouncilChalk River LaboratoriesCanada
  2. 2.Department of PhysicsUniversity of GuelphGuelphCanada
  3. 3.Department of PhysicsSt. Francis Xavier UniversityAntigonishCanada