Journal of Molecular Medicine

, Volume 79, Issue 8, pp 419–427

CD3+CD4CD8 αβ-TCR+ T cell as immune regulatory cell

Authors

  • Zhu Zhang
    • Multi-Organ Transplantation Program, Toronto General Hospital Research Institute, University Health Network, 101 College Street, CCRW2-815, Toronto, M5A 1E7, Canada
  • Kevin Young
    • Multi-Organ Transplantation Program, Toronto General Hospital Research Institute, University Health Network, 101 College Street, CCRW2-815, Toronto, M5A 1E7, Canada
  • Li Zhang
    • Multi-Organ Transplantation Program, Toronto General Hospital Research Institute, University Health Network, 101 College Street, CCRW2-815, Toronto, M5A 1E7, Canada
Review

DOI: 10.1007/s001090100238

Cite this article as:
Zhang, Z., Young, K. & Zhang, L. J Mol Med (2001) 79: 419. doi:10.1007/s001090100238

Abstract

Down-regulation of immune responses by regulatory T cells is one of the major mechanisms involved in the induction of tolerance to self- and alloantigens as demonstrated in a number of models of transplantation and autoimmunity. It is clear that regulatory T cells consist of different subsets. Recently a novel subset of antigen-specific αβ-TCR+ CD4CD8 (double negative, DN) regulatory T cells has been found to be able to inhibit the function of the CD8+ T cells carrying the same T cell receptor specificity and prevent the rejection of skin allografts. Identification of the DN regulatory T cells and their novel mechanism of suppression can help us to understand how donor-specific transplantation tolerance can be achieved and to explain how tolerance to self-antigens can be maintained in the periphery.

Transplantation Tolerance Regulatory Suppression Antigen

Copyright information

© Springer-Verlag 2001