Journal of Molecular Medicine

, Volume 79, Issue 4, pp 198–204

A polymorphism, L162V, in the peroxisome proliferator-activated receptor α (PPARα) gene is associated with lower body mass index in patients with non-insulin-dependent diabetes mellitus

Authors

  • D. Evans
    • Klinik und Poliklinik für Innere Medizin, Universitätsklinikum Eppendorf, Martinistrasse 52, 20251 Hamburg
  • J. Aberle
    • Klinik und Poliklinik für Innere Medizin, Universitätsklinikum Eppendorf, Martinistrasse 52, 20251 Hamburg
  • D. Wendt
    • Klinik und Poliklinik für Innere Medizin, Universitätsklinikum Eppendorf, Martinistrasse 52, 20251 Hamburg
  • A. Wolf
    • Klinik für Allgemeinchirurgie, Evangelisches und Johanniter Klinikum, Kreuzstrasse 28, 46535 Dinslaken
  • U. Beisiegel
    • Klinik und Poliklinik für Innere Medizin, Universitätsklinikum Eppendorf, Martinistrasse 52, 20251 Hamburg
  • W. Mann
    • Klinik und Poliklinik für Innere Medizin, Universitätsklinikum Eppendorf, Martinistrasse 52, 20251 Hamburg
Original article

DOI: 10.1007/s001090100189

Cite this article as:
Evans, D., Aberle, J., Wendt, D. et al. J Mol Med (2001) 79: 198. doi:10.1007/s001090100189

Abstract

This study examined the effect a polymorphism (L162V) in the gene for peroxisome proliferator activated receptor (PPAR) α in the development of non-insulin-dependent diabetes mellitus (type 2 DM), obesity and hyperlipidaemia. The frequency of the L162V polymorphism in the PPARα gene was determined in 370 morbidly obese patients who underwent gastric banding surgery, 154 patients attending a type 2 DM clinic, 188 patients attending a lipid clinic and 199 healthy blood donors. The overall frequency of the V allele of the L162V polymorphism was 0.06. There were no significant differences in the allele frequency between patients with morbid obesity, hyperlipidaemia, type 2 DM and healthy controls, suggesting that it does not play a major role in the development of these conditions. The polymorphism was associated with a lower body mass index (BMI) in two independently recruited groups of patients with type 2 DM. There was no effect of the polymorphism on subjects without type 2 DM. Thus a polymorphism in PPARα protects type 2 DM patients from the overweight which is frequently associated with their condition.

PPARα polymorphism Obesity Type 2 DM

Copyright information

© Springer-Verlag 2001