Journal of Molecular Medicine

, Volume 76, Issue 8, pp 581–588

Glucose-6-phosphate dehydrogenase deficiency and malaria

  • C. Ruwende
  • Adrian Hill

DOI: 10.1007/s001090050253

Cite this article as:
Ruwende, C. & Hill, A. J Mol Med (1998) 76: 581. doi:10.1007/s001090050253


 Glucose-6-phosphate dehydrogenase (G6PD) is a cytoplasmic enzyme that is essential for a cell’s capacity to withstand oxidant stress. G6PD deficiency is the commonest enzymopathy of humans, affecting over 400 million persons worldwide. The geographical correlation of its distribution with the historical endemicity of malaria suggests that 66PD deficiency has risen in frequency through natural selection by malaria. This is supported by data from in vitro studies that demonstrate impaired growth of P. falciparum parasites in G6PD-deficient erythrocytes. Attempts to confirm that G6PD deficiency is protective in field studies of malaria have yielded conflicting results, but recent results from large case control studies conducted in East and West Africa provide strong evidence that the most common African G6PD deficiency variant, G6PD A, is associated with a significant reduction in the risk of severe malaria for both G6PD female heterozygotes and male hemizygotes. The effect of female homozygotes on severe malaria remains unclear but can probably be assumed to be similar to that of comparably deficient male hemizygotes.

Key words Glucose-6-phosphate dehydrogenase deficiencySevere malariaProtectionHeterozygotesHemizygotes

Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • C. Ruwende
    • 1
  • Adrian Hill
    • 2
  1. 1.Department of Medicine, Johns Hopkins Medical Institutions, 1830 East Monument Street, Baltimore, MD 21205, USATP
  2. 2.Wellcome Trust Centre for Human Genetics, University of Oxford, Windmill Road, Oxford OX 3 7BN, UKGB