Journal of Molecular Medicine

, Volume 76, Issue 3, pp 266–274

Pathogenesis of fibrosis: type 1 collagen and the skin

Authors

  • Maria Trojanowska
    • Department of Medicine, Division of Rheumatology and Immunology, Medical University of South Carolina, 171 Ashley Avenue, Charleston, SC 29425, USA
  • E.  Carwile LeRoy
    • Departments of Medicine, and Microbiology and Immunology, Division of Rheumatology and Immunology, Medical University of South Carolina, 171 Ashley Avenue, Charleston, SC 29425, USA, and Department of Dermatology, University of Cologne School of Medicine, Cologne, Germany
  • Beate Eckes
    • Department of Dermatology, University of Cologne School of Medicine, Cologne, Germany
  • Thomas Krieg
    • Department of Dermatology, University of Cologne School of Medicine, Cologne, Germany
REVIEW

DOI: 10.1007/s001090050216

Cite this article as:
Trojanowska, M., Carwile LeRoy, E., Eckes, B. et al. J Mol Med (1998) 76: 266. doi:10.1007/s001090050216

Abstract

This review on the pathogenesis of fibrosis emphasizes the similarities between tissue repair, a tightly regulated salutary biological response, and fibrosis, an unregulated pathological process. It focuses on the transcriptional regulation of type I collagen, the role of cytokines in fibroblast activation, integrins as examples of cell-matrix signaling pathways, and the heterogeneity of fibroblast populations as factors contributing to fibrosis. Tissue remodeling and the role of matrix metalloproteinases and metalloproteinase inhibitors are mentioned briefly. The capacity of extracellular matrix to modulate cellular function is a recurring theme.

Key words Fibrosis Collagen type I Transcriptional regulation Cytokines Integrins AbbreviationsAP Activator protein CBF CCAAT binding factor CTGF Connective tissue growth factor ECM Extracellular matrix IL Interleukin MMP Matrix metalloproteinase NF Nuclear factor PDGF Platelet-derived growth factor SSc Systemic sclerosis TGF Transforming growth factor TIMP Tissue inhibitor of metalloproteinase

Copyright information

© Springer-Verlag Berlin Heidelberg 1998