Journal of Molecular Medicine

, Volume 76, Issue 2, pp 141-146

First online:

Three alternatively spliced variants of the gene coding for the human bone morphogenetic protein-1

  • Michal JanitzAffiliated withDeutsches Rheuma-Forschungszentrum, Hannoversche Strasse 27, D-10115 Berlin, Germany
  • , Volker HeiserAffiliated withInstitut für Genbiologische Forschung Berlin GmbH, Berlin, Germany
  • , U. BöttcherAffiliated withTIB MolBiol, Berlin, Germany
  • , Olfert LandtAffiliated withTIB MolBiol, Berlin, Germany
  • , R. LausterAffiliated withDeutsches Rheuma-Forschungszentrum, Hannoversche Strasse 27, D-10115 Berlin, Germany

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 The human bone morphogenetic protein-1 was originally identified as a protein with the capacity to stimulate bone and cartilage growth in vitro. Its gene sequence identified it as an alternatively spliced human homolog of the Drosophila dorsal-ventral patterning tolloid gene and suggested that it activates transforming growth factor-β-like molecules by proteolytic cleavage. Its expression pattern and its recently identified activity as a procollagen C proteinase, however, suggest that it has a more general function in the early stages of embryogenesis. This view is strengthened by the previous observation of a third alternatively spliced isoform of the gene, called bone morphogenetic protein 1/His. We now show that the gene is expressed in three additional variants, leading to shorter and slightly modified C-termini. The three variants are preferentially expressed in placenta but show individual differences in their expression profiles in other soft tissues.

Key words Bone morphogenetic protein Morphogenesis Alternative splicing Tissue-specific expression Transcription