Journal of Molecular Medicine

, Volume 75, Issue 5, pp 317–326

STAT6: its role in interleukin 4-mediated biological functions

  • K. Takeda
  • Tadamitsu Kishimoto
  • Shizuo Akira
REVIEW

DOI: 10.1007/s001090050117

Cite this article as:
Takeda, K., Kishimoto, T. & Akira, S. J Mol Med (1997) 75: 317. doi:10.1007/s001090050117

Abstract

 Interleukin (IL) 4 is known to be a cytokine which plays a central role in the regulation of immune response. Studies on cytokine signal transduction have clarified the mechanism by which IL4 exerts its functions. Two cytoplasmic proteins, signal transducer and activator of transcription (STAT) 6 and IL4-induced phosphotyrosine substrate/insulin receptor substrate 2 (4PS/IRS2), are activated in IL4 signal transduction. Recent studies from STAT6-deficient mice have revealed the essential role of STAT6 in IL4-mediated biological actions. In addition, STAT6 has also been demonstrated to be important for the functions mediated by IL13, which is related to IL4. IL4 and IL13 have been shown to induce the production of IgE, which is a major mediator in an allergic response. These findings indicate that STAT6 activation is involved in IL4- and IL13-mediated disorders such as allergy.

Key words Interleukin 4Signal transducer and activator of transcription 6IL4-induced phosphotyrosine substrate/insulin receptor substrateInterleukin 13Signal transduction

Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • K. Takeda
    • 1
  • Tadamitsu Kishimoto
    • 2
  • Shizuo Akira
    • 3
  1. 1.Department of Biochemistry, Hyogo College of Medicine, 1-1, Mukogawa-cho, Nishinomiya, Hyogo, 663, and Department of Medicine III, Osaka University Medical School, 2-2, Yamada-oka, Suita, Osaka, 565, JapanJP
  2. 2.Department of Medicine III, Osaka University Medical School, 2-2, Yamada-oka, Suita, Osaka, 565, JapanJP
  3. 3.Department of Biochemistry, Hyogo College of Medicine, 1-1, Mukogawa-cho, Nishinomiya, Hyogo, 663, JapanJP