Journal of Molecular Medicine

, Volume 75, Issue 1, pp 57–61

Relationship of polymorphisms in the renin-angiotensin system and in E-selectin of patients with early severe coronary heart disease

Authors

  • K. Wenzel
    • Department of Internal Medicine I, Cardiology, Division of Molecular Biology, Charité, Humboldt University, Ziegelstrasse 5–9, D-10117 Berlin, Germany
  • A. Blackburn
    • Department of Internal Medicine I, Cardiology, Division of Molecular Biology, Charité, Humboldt University, Ziegelstrasse 5–9, D-10117 Berlin, Germany
  • M. Ernst
    • Department of Internal Medicine I, Cardiology, Division of Molecular Biology, Charité, Humboldt University, Ziegelstrasse 5–9, D-10117 Berlin, Germany
  • M. Affeldt
    • Department of Internal Medicine I, Cardiology, Division of Molecular Biology, Charité, Humboldt University, Ziegelstrasse 5–9, D-10117 Berlin, Germany
  • R. Hanke
    • Department of Internal Medicine I, Cardiology, Division of Molecular Biology, Charité, Humboldt University, Ziegelstrasse 5–9, D-10117 Berlin, Germany
  • G. Baumann
    • Department of Internal Medicine I, Cardiology, Charité, Humboldt University, D-10098 Berlin, Germany
  • S. B. Felix
    • Department of Internal Medicine I, Cardiology, Charité, Humboldt University, D-10098 Berlin, Germany
  • F. X. Kleber
    • Department of Internal Medicine I, Cardiology, Charité, Humboldt University, D-10098 Berlin, Germany
  • K. Rohde
    • Max-Delbrück-Center of Molecular Medicine, D-13122 Berlin, Germany
  • C. Gläser
    • Institut of Human Genetics, University Halle, D-06097 Halle, Germany
  • A. Speer
    • Department of Internal Medicine I, Cardiology, Division of Molecular Biology, Charité, Humboldt University, Ziegelstrasse 5–9, D-10117 Berlin, Germany
ORIGINAL ARTICLE

DOI: 10.1007/s001090050087

Cite this article as:
Wenzel, K., Blackburn, A., Ernst, M. et al. J Mol Med (1997) 75: 57. doi:10.1007/s001090050087

Abstract

 Previous association studies between angiotensin-converting enzyme (ACE) and angiotensinogen (AGT) polymorphisms and several cardiovascular diseases have reported variable results. Therefore we examined the association of the DNA variants of ACE and AGT with early, severe coronary heart disease (CHD). In addition, we compared the genotypes of both polymorphisms and the recently discovered polymorphism in the E-selectin gene in both patients and an unselected population. This study included 113 patients with severe CHD (50 years old or less) and up to 197 control subjects. The frequencies of the ACE I/D variants were 48% I and 52% D in the controls and 46% I and 54% D in the patients. The frequencies of the AGT-M235T polymorphism were 60.8% M and 39.2% T in controls and 49.1% M and 50.9% T in the patients. The frequencies of the S128R polymorphism of the E-selectin were 91.3% S and 8.7% R in controls and 84.5% S and 15.5% R in the patients. In our studies the DD genotype of ACE was not associated with early severe CHD. We found a correlation between the M235T molecular variant of AGT and the S128R variant of E-selectin to early severe CHD.

Key words Coronary heart diseaseGenotypeangiotensinogenAngiotensin-converting enzymeE-selectin

Copyright information

© Springer-Verlag Berlin Heidelberg 1997