Journal of Molecular Medicine

, Volume 74, Issue 12, pp 749–769

The NF-κB/Rel and IκB gene families: mediators of immune response and inflammation

  • F. Gregory Wulczyn
  • Daniel Krappmann
  • C. Scheidereit
REVIEW

DOI: 10.1007/s001090050078

Cite this article as:
Wulczyn, F., Krappmann, D. & Scheidereit, C. J Mol Med (1996) 74: 749. doi:10.1007/s001090050078

Abstract

 Two families of gene regulators play an important role in cellular signaling processes in vertebrates: the nuclear factor κB (NF-κB)/Rel group of transcription activators and their coevolved regulatory proteins, the inhibitors of κB (IκBs). The biological functions of NF-κB comprise communication between cells, embryonal development, the response to stress, inflammation and viral infection, and the maintenance of cell type specific expression of genes. In several pathogenic conditions components of the NF-κB system are deregulated and could thus present potential diagnostic probes or targets for therapeutic intervention.

Key words Transcription factorsOncogenesSignal transductionNF-κBIκB

Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • F. Gregory Wulczyn
    • 1
  • Daniel Krappmann
    • 1
  • C. Scheidereit
    • 1
  1. 1.Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Strasse 10, D-13122 Berlin, GermanyDE