Journal of Molecular Medicine

, Volume 74, Issue 12, pp 725–747

Jun: transcription factor and oncoprotein

  • Hans J. Rahmsdorf

DOI: 10.1007/s001090050077

Cite this article as:
Rahmsdorf, H. J Mol Med (1996) 74: 725. doi:10.1007/s001090050077


 Since the discovery of v-jun as the transforming protein of the sarcoma virus 17 three mammalian homologues of v-jun have been isolated. All three jun genes respond to a multitude of agents, and the encoded proteins in turn bind to and regulate, positively or negatively, the transcription of dependent genes, thereby influencing cellular fate. In addition, through transcription factor ”cross-talk” Jun influences the transcription of genes regulated by different classes of transcription factors, such as steroid hormone receptors. Although the role of Jun proteins in transcriptional regulation has been thoroughly analyzed in recent years, the role of Jun proteins in oncogenesis is still poorly understood.

Key words Activator protein 1 Protein phosphorylation Proline-directed protein kinases Glucocorticoid receptor Stress response 

Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • Hans J. Rahmsdorf
    • 1
  1. 1.Forschungszentrum Karlsruhe, Institut für Genetik, P.O. Box 3640, D-76021 Karlsruhe, GermanyDE