Journal of Molecular Medicine

, Volume 78, Issue 12, pp 708–720

Natural zeolite clinoptilolite: new adjuvant in anticancer therapy

  • Krešimir Pavelić
  • Mirko Hadžija
  • Ljiljana Bedrica
  • Jasminka Pavelić
  • Ivan Ðikić
  • Maša Katić
  • Marijeta Kralj
  • Maja Herak Bosnar
  • Sanja Kapitanović
  • Marija Poljak-Blaži
  • Šimun Križanac
  • Ranko Stojković
  • Mislav Jurin
  • Boris Subotić
  • Miroslav Čolić
Original Article

DOI: 10.1007/s001090000176

Cite this article as:
Pavelić, K., Hadžija, M., Bedrica, L. et al. J Mol Med (2001) 78: 708. doi:10.1007/s001090000176

Abstract

Natural silicate materials, including zeolite clinoptilolite, have been shown to exhibit diverse biological activities and have been used successfully as a vaccine adjuvant and for the treatment of diarrhea. We report a novel use of finely ground clinoptilolite as a potential adjuvant in anticancer therapy. Clinoptilolite treatment of mice and dogs suffering from a variety of tumor types led to improvement in the overall health status, prolongation of life-span, and decrease in tumors size. Local application of clinoptilolite to skin cancers of dogs effectively reduced tumor formation and growth. In addition, toxicology studies on mice and rats demonstrated that the treatment does not have negative effects. In vitro tissue culture studies showed that finely ground clinoptilolite inhibits protein kinase B (c-Akt), induces expression of p21WAF1/CIP1 and p27KIP1 tumor suppressor proteins, and blocks cell growth in several cancer cell lines. These data indicate that clinoptilolite treatment might affect cancer growth by attenuating survival signals and inducing tumor suppressor genes in treated cells.

Clinoptilolite Adjuvant Anticancer Treatment

Copyright information

© Springer-Verlag 2001

Authors and Affiliations

  • Krešimir Pavelić
    • 1
  • Mirko Hadžija
    • 1
  • Ljiljana Bedrica
    • 2
  • Jasminka Pavelić
    • 1
  • Ivan Ðikić
    • 3
  • Maša Katić
    • 1
  • Marijeta Kralj
    • 1
  • Maja Herak Bosnar
    • 1
  • Sanja Kapitanović
    • 1
  • Marija Poljak-Blaži
    • 1
  • Šimun Križanac
    • 4
  • Ranko Stojković
    • 1
  • Mislav Jurin
    • 1
  • Boris Subotić
    • 1
  • Miroslav Čolić
    • 5
  1. 1.Ruđer Bošković Institute, Division of Molecular Medicine and Division of Material Chemistry, Bijenička 54, ZagrebCroatia
  2. 2.Veterinary Faculty, University of Zagreb, Heinzelova 55, 10001 ZagrebCroatia
  3. 3.Ludwig Institute for Cancer Research, Biomedical Center, Husargatan 3, UppsalaSweden
  4. 4.Institute of Pathology, Faculty of Medicine, University of Zagreb, Šalata 11, ZagrebCroatia
  5. 5.Molecular Technologies Inc., 6512 Segovia, Goleta, CA 93117USA