Original Article

Journal of Molecular Medicine

, Volume 78, Issue 12, pp 708-720

First online:

Natural zeolite clinoptilolite: new adjuvant in anticancer therapy

  • Krešimir PavelićAffiliated withRuđer Bošković Institute, Division of Molecular Medicine and Division of Material Chemistry, Bijenička 54, Zagreb
  • , Mirko HadžijaAffiliated withRuđer Bošković Institute, Division of Molecular Medicine and Division of Material Chemistry, Bijenička 54, Zagreb
  • , Ljiljana BedricaAffiliated withVeterinary Faculty, University of Zagreb, Heinzelova 55, 10001 Zagreb
  • , Jasminka PavelićAffiliated withRuđer Bošković Institute, Division of Molecular Medicine and Division of Material Chemistry, Bijenička 54, Zagreb
  • , Ivan ÐikićAffiliated withLudwig Institute for Cancer Research, Biomedical Center, Husargatan 3, Uppsala
  • , Maša KatićAffiliated withRuđer Bošković Institute, Division of Molecular Medicine and Division of Material Chemistry, Bijenička 54, Zagreb
  • , Marijeta KraljAffiliated withRuđer Bošković Institute, Division of Molecular Medicine and Division of Material Chemistry, Bijenička 54, Zagreb
  • , Maja Herak BosnarAffiliated withRuđer Bošković Institute, Division of Molecular Medicine and Division of Material Chemistry, Bijenička 54, Zagreb
  • , Sanja KapitanovićAffiliated withRuđer Bošković Institute, Division of Molecular Medicine and Division of Material Chemistry, Bijenička 54, Zagreb
    • , Marija Poljak-BlažiAffiliated withRuđer Bošković Institute, Division of Molecular Medicine and Division of Material Chemistry, Bijenička 54, Zagreb
    • , Šimun KrižanacAffiliated withInstitute of Pathology, Faculty of Medicine, University of Zagreb, Šalata 11, Zagreb
    • , Ranko StojkovićAffiliated withRuđer Bošković Institute, Division of Molecular Medicine and Division of Material Chemistry, Bijenička 54, Zagreb
    • , Mislav JurinAffiliated withRuđer Bošković Institute, Division of Molecular Medicine and Division of Material Chemistry, Bijenička 54, Zagreb
    • , Boris SubotićAffiliated withRuđer Bošković Institute, Division of Molecular Medicine and Division of Material Chemistry, Bijenička 54, Zagreb
    • , Miroslav ČolićAffiliated withMolecular Technologies Inc., 6512 Segovia, Goleta, CA 93117

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Abstract

Natural silicate materials, including zeolite clinoptilolite, have been shown to exhibit diverse biological activities and have been used successfully as a vaccine adjuvant and for the treatment of diarrhea. We report a novel use of finely ground clinoptilolite as a potential adjuvant in anticancer therapy. Clinoptilolite treatment of mice and dogs suffering from a variety of tumor types led to improvement in the overall health status, prolongation of life-span, and decrease in tumors size. Local application of clinoptilolite to skin cancers of dogs effectively reduced tumor formation and growth. In addition, toxicology studies on mice and rats demonstrated that the treatment does not have negative effects. In vitro tissue culture studies showed that finely ground clinoptilolite inhibits protein kinase B (c-Akt), induces expression of p21WAF1/CIP1 and p27KIP1 tumor suppressor proteins, and blocks cell growth in several cancer cell lines. These data indicate that clinoptilolite treatment might affect cancer growth by attenuating survival signals and inducing tumor suppressor genes in treated cells.

Clinoptilolite Adjuvant Anticancer Treatment