Journal of Molecular Medicine

, Volume 79, Issue 1, pp 21–29

The renin-angiotensin system and natriuretic peptides in obesity-associated hypertension

  • Stefan Engeli
  • Arya M. Sharma

DOI: 10.1007/s001090000144

Cite this article as:
Engeli, S. & Sharma, A. J Mol Med (2001) 79: 21. doi:10.1007/s001090000144


Excessive accumulation of adipose tissue is associated with profound alterations in the cardiovascular system, including an increase in systemic blood pressure. It now appears clear that a central feature of obesity-associated hypertension is related to changes in sodium handling that may result from abnormalities in sympathetic nervous system activity, the renin-angiotensin-aldosterone system, natriuretic peptides, and kidney function. In this paper we review the role of these factors in the development of obesity-associated hypertension, thereby focusing on the potential role of adipose tissue in these alterations.

Adipose tissue Hypertension Obesity Atrial natriuretic peptide Renin-angiotensin system 

Copyright information

© Springer-Verlag 2000

Authors and Affiliations

  • Stefan Engeli
    • 1
  • Arya M. Sharma
    • 1
  1. 1.Department of Nephrology and Hypertension, Franz-Volhard-Klinik, Universitätsklinikum Charité, Humboldt Universität, Wiltbergstrasse 50, 13122 Berlin, GermanyGermany

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